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evidence · mechanism · dose
Supplements/Herb

Gotu Kola

aka Centella asiatica

Adaptogen used for cognitive support, anxiety, and wound healing.

Brain & CognitiveMood & AnxietySkin, Hair & Nails

Overview

Adaptogen used for cognitive support, anxiety, and wound healing.

Natural sources
  • Centella asiatica
Common forms
  • Standardized asiaticosides

Forms & variants of Gotu Kola

Different chemical forms of Gotu Kola behave differently. Browse each form's mechanism, bioavailability, and best-use context.

TECA standardized
Gotu Kola (Extra)

Standardized triterpenes for venous insufficiency and skin healing.

Mechanism of action

Triterpenes (asiaticoside, madecassoside) support collagen synthesis and BDNF.

Pathways
  • · BDNF ↑
  • · Collagen synthesis

Effects on the body

Supports
Wound healing
Decreases
Anxiety

Organ system effects

Skin

Speeds wound healing topically and orally.

Brain & CNS

Improves anxiety and cognition.

Evidence-based benefits

Improves wound healing and scar quality

Moderate evidence

Reduces anxiety

Limited evidence

Potential side effects

Common
  • · GI upset
Rare
  • · Hepatotoxicity (rare)
Serious

    Drug interactions

    Hepatotoxic drugs
    Theoretical caution.
    minor

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    500–1000 mg standardized

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Herb
    Gotu Kola
    Amazon
    Wide selection · fast shipping
    Herb
    Gotu Kola
    iHerb
    Global delivery · curated brands
    Herb
    Gotu Kola
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (9)

    Systematic reviewExamine.com Supplement Database · 2023

    Gotu Kola: pharmacology, clinical evidence, and safety — narrative review

    Examine.com Research Team

    Curated narrative review of human and preclinical evidence for Gotu Kola, including mechanism, typical dosing, and safety considerations.

    Key findings

    Best-supported outcome: Improves wound healing and scar quality (evidence: moderate). Additional outcomes and limitations summarized in the full profile.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — Improves wound healing and scar quality

    Live PubMed search

    Live results for "Gotu Kola Improves wound healing and scar quality" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "Improves wound healing and scar quality". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — Reduces anxiety

    Live PubMed search

    Live results for "Gotu Kola Reduces anxiety" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "Reduces anxiety". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — randomized controlled trial

    Live PubMed search

    Live results for "Gotu Kola randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — meta-analysis

    Live PubMed search

    Live results for "Gotu Kola meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — pharmacokinetics

    Live PubMed search

    Live results for "Gotu Kola pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — safety adverse events

    Live PubMed search

    Live results for "Gotu Kola safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Gotu Kola — dose response

    Live PubMed search

    Live results for "Gotu Kola dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Gotu Kola and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Gotu Kola — clinical evidence

    Live Scholar search

    Cross-database citation index for Gotu Kola as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.