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evidence · mechanism · dose
Supplements/Herb

Gotu Kola (Extra)

Standardized triterpenes for venous insufficiency and skin healing.

Skin, Hair & Nails

Overview

Standardized triterpenes for venous insufficiency and skin healing.

Natural sources
    Common forms

      Forms & variants of Gotu Kola

      Different chemical forms of Gotu Kola behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Gotu Kola

      Adaptogen used for cognitive support, anxiety, and wound healing.

      Mechanism of action

      Asiaticoside and madecassoside upregulate collagen and capillary integrity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces chronic venous insufficiency symptoms

        Strong evidence

        Potential side effects

        Common
        • · Skin irritation (topical)
        Rare
        • · Hepatotoxicity (rare)
        Serious

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          60–180 mg TECA
          With food?
          With food

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
          Gotu Kola (E…
          Amazon
          Wide selection · fast shipping
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          iHerb
          Global delivery · curated brands
          Herb
          Gotu Kola (E…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          RCTAngiology · 1987

          TECA for chronic venous insufficiency

          Pointel JP, et al.

          DB-RCT in 94 patients with CVI.

          Key findings

          Significantly improved symptoms vs placebo over 2 months.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — Reduces chronic venous insufficiency symptoms

          Live PubMed search

          Live results for "Gotu Kola (Extra) Reduces chronic venous insufficiency symptoms" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "Reduces chronic venous insufficiency symptoms". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — randomized controlled trial

          Live PubMed search

          Live results for "Gotu Kola (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — meta-analysis

          Live PubMed search

          Live results for "Gotu Kola (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — pharmacokinetics

          Live PubMed search

          Live results for "Gotu Kola (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — safety adverse events

          Live PubMed search

          Live results for "Gotu Kola (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Gotu Kola (Extra) — dose response

          Live PubMed search

          Live results for "Gotu Kola (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Gotu Kola (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Gotu Kola (Extra) — clinical evidence

          Live Scholar search

          Cross-database citation index for Gotu Kola (Extra) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.