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evidence · mechanism · dose
Supplements/Herb

Centella Asiatica (Gotu Kola)

Traditional brain and skin tonic — supports cognition and wound healing.

MemoryAnxiety SupportSkin HealthCollagen Production

Overview

Traditional brain and skin tonic — supports cognition and wound healing.

Natural sources
    Common forms

      Forms & variants of Centella Asiatica (Gotu Kola)

      Different chemical forms of Centella Asiatica (Gotu Kola) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Skin / scar dose
      Centella asiatica (Skin)

      Standardized titrated extract for scars and venous skin changes.

      Mechanism of action

      Asiaticosides upregulate collagen synthesis and BDNF.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves wound healing and scarring

        Moderate evidence

        Mild anxiolytic

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid if you are
              • ·Pregnant or breastfeeding (insufficient safety data)
              • ·Children under 18 (unless directed by a clinician)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              500–1000 mg
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Herb
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              Amazon
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              iHerb
              Global delivery · curated brands
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              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (9)

              RCTJ Clin Psychopharmacol · 2000

              Centella asiatica for anxiety

              Bradwejn J, et al.

              RCT of Centella on acoustic startle response.

              Key findings

              Reduced acute anxiety response.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — Improves wound healing and scarring

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) Improves wound healing and scarring" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "Improves wound healing and scarring". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — Mild anxiolytic

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) Mild anxiolytic" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "Mild anxiolytic". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — randomized controlled trial

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — meta-analysis

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — pharmacokinetics

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — safety adverse events

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Centella Asiatica (Gotu Kola) — dose response

              Live PubMed search

              Live results for "Centella Asiatica (Gotu Kola) dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Centella Asiatica (Gotu Kola) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Centella Asiatica (Gotu Kola) — clinical evidence

              Live Scholar search

              Cross-database citation index for Centella Asiatica (Gotu Kola) as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.