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evidence · mechanism · dose
Supplements/Herb

Centella asiatica (Skin)

Standardized titrated extract for scars and venous skin changes.

Skin, Hair & Nails

Overview

Standardized titrated extract for scars and venous skin changes.

Natural sources
    Common forms

      Forms & variants of Centella Asiatica (Gotu Kola)

      Different chemical forms of Centella Asiatica (Gotu Kola) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Centella Asiatica (Gotu Kola)

      Traditional brain and skin tonic — supports cognition and wound healing.

      Mechanism of action

      Asiatic acid and madecassic acid stimulate fibroblast collagen and reduce TGF-β driven fibrosis.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces hypertrophic scarring

        Moderate evidence

        Potential side effects

        Common
        • · Skin irritation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            60–120 mg TECA
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Centella asi…
            Amazon
            Wide selection · fast shipping
            Herb
            Centella asi…
            iHerb
            Global delivery · curated brands
            Herb
            Centella asi…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTAesthetic Plast Surg · 2000

            Centella on scar prevention

            Widgerow AD, et al.

            Trial in post-surgical patients.

            Key findings

            Topical centella reduced scar hypertrophy vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — Reduces hypertrophic scarring

            Live PubMed search

            Live results for "Centella asiatica (Skin) Reduces hypertrophic scarring" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "Reduces hypertrophic scarring". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — randomized controlled trial

            Live PubMed search

            Live results for "Centella asiatica (Skin) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — meta-analysis

            Live PubMed search

            Live results for "Centella asiatica (Skin) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — pharmacokinetics

            Live PubMed search

            Live results for "Centella asiatica (Skin) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — safety adverse events

            Live PubMed search

            Live results for "Centella asiatica (Skin) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Centella asiatica (Skin) — dose response

            Live PubMed search

            Live results for "Centella asiatica (Skin) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Centella asiatica (Skin) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Centella asiatica (Skin) — clinical evidence

            Live Scholar search

            Cross-database citation index for Centella asiatica (Skin) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.