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Centella asiatica (Skin)

Standardized titrated extract for scars and venous skin changes.

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Overview

Standardized titrated extract for scars and venous skin changes.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Forms & variants of Centella Asiatica (Gotu Kola)

Different chemical forms of Centella Asiatica (Gotu Kola) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Asiatic acid and madecassic acid stimulate fibroblast collagen and reduce TGF-β driven fibrosis.

Pathways
  • · Asiatic acid
  • · madecassic acid stimulate fibroblast collagen
  • · reduce TGF-β driven fibrosis

Effects on the body

Decreases
hypertrophic scarring

Organ system effects

Skin

Centella asiatica (Skin) supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Evidence-based benefits

Reduces hypertrophic scarring

Moderate evidence

Potential side effects

Common
  • · Skin irritation
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Centella asiatica (Skin) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with
      • Collagen peptides
        Provides amino acid substrate for connective tissue synthesis.
      • Vitamin C
        Required cofactor for collagen hydroxylation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      60–120 mg TECA
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With food

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTAesthetic Plast Surg · 2000

      Centella on scar prevention

      Widgerow AD, et al.

      Trial in post-surgical patients.

      Key findings

      Topical centella reduced scar hypertrophy vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — Reduces hypertrophic scarring

      Live PubMed search

      Live results for "Centella asiatica (Skin) Reduces hypertrophic scarring" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "Reduces hypertrophic scarring". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — randomized controlled trial

      Live PubMed search

      Live results for "Centella asiatica (Skin) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — meta-analysis

      Live PubMed search

      Live results for "Centella asiatica (Skin) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — pharmacokinetics

      Live PubMed search

      Live results for "Centella asiatica (Skin) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — safety adverse events

      Live PubMed search

      Live results for "Centella asiatica (Skin) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Centella asiatica (Skin) — dose response

      Live PubMed search

      Live results for "Centella asiatica (Skin) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Centella asiatica (Skin) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Centella asiatica (Skin) — clinical evidence

      Live Scholar search

      Cross-database citation index for Centella asiatica (Skin) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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