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evidence · mechanism · dose
Supplements/Compound

Phenibut (Ref)

GABA-B agonist developed in the USSR for anxiety (caution).

Mood & Anxiety

Overview

GABA-B agonist developed in the USSR for anxiety (caution).

Natural sources
    Common forms

      Forms & variants of Phenibut (caution)

      Different chemical forms of Phenibut (caution) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Phenibut (caution)

      GABA-B agonist with high abuse and dependence potential; restricted in many countries.

      Mechanism of action

      GABA-B receptor agonism and α2δ calcium channel binding.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces anxiety and improves social comfort

        Limited evidence

        Potential side effects

        Common
        • · Sedation
        Rare
          Serious
          • · Tolerance, dependence, withdrawal

          Drug interactions

          CNS depressants/Alcohol
          Respiratory depression risk.
          severe

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          Discouraged outside Rx settings

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Compound
          Phenibut (Ref)
          Amazon
          Wide selection · fast shipping
          Compound
          Phenibut (Ref)
          iHerb
          Global delivery · curated brands
          Compound
          Phenibut (Ref)
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          CohortAust N Z J Psychiatry · 2016

          Phenibut withdrawal case series

          Owen DR, et al.

          Case series of phenibut withdrawal.

          Key findings

          Severe withdrawal mimicking baclofen + benzodiazepine.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — Reduces anxiety and improves social comfort

          Live PubMed search

          Live results for "Phenibut (Ref) Reduces anxiety and improves social comfort" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "Reduces anxiety and improves social comfort". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — randomized controlled trial

          Live PubMed search

          Live results for "Phenibut (Ref) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — meta-analysis

          Live PubMed search

          Live results for "Phenibut (Ref) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — pharmacokinetics

          Live PubMed search

          Live results for "Phenibut (Ref) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — safety adverse events

          Live PubMed search

          Live results for "Phenibut (Ref) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Phenibut (Ref) — dose response

          Live PubMed search

          Live results for "Phenibut (Ref) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Phenibut (Ref) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Phenibut (Ref) — clinical evidence

          Live Scholar search

          Cross-database citation index for Phenibut (Ref) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.