Overview
GABA-B agonist developed in the USSR for anxiety (caution).
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Forms & variants of Phenibut (caution)
Different chemical forms of Phenibut (caution) behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
GABA-B receptor agonism and α2δ calcium channel binding.
- · GABA-B receptor agonism
- · α2δ calcium channel binding
Effects on the body
Organ system effects
Phenibut (Ref) modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.
Evidence-based benefits
Reduces anxiety and improves social comfort
Limited evidencePotential side effects
- · Sedation
- · Tolerance, dependence, withdrawal
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Phenibut (Ref) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Phenibut (Ref) third party tested NSF
CapsulesPre-measured Phenibut (Ref) capsules — easiest for travel and consistent daily dosing without scoops or scales.Phenibut (Ref) capsules
PowderBulk unflavored Phenibut (Ref) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Phenibut (Ref) powder unflavored
Best sellersMost-purchased Phenibut (Ref) products on Amazon — a quick way to see what's reviewed widely before you commit.Phenibut (Ref) best sellerScientific evidence8Show studiesHide studies
Phenibut withdrawal case series
Owen DR, et al.
Case series of phenibut withdrawal.
Severe withdrawal mimicking baclofen + benzodiazepine.
PubMed: Phenibut (Ref) — Reduces anxiety and improves social comfort
Live PubMed search
Live results for "Phenibut (Ref) Reduces anxiety and improves social comfort" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "Reduces anxiety and improves social comfort". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Phenibut (Ref) — randomized controlled trial
Live PubMed search
Live results for "Phenibut (Ref) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Phenibut (Ref) — meta-analysis
Live PubMed search
Live results for "Phenibut (Ref) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Phenibut (Ref) — pharmacokinetics
Live PubMed search
Live results for "Phenibut (Ref) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Phenibut (Ref) — safety adverse events
Live PubMed search
Live results for "Phenibut (Ref) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Phenibut (Ref) — dose response
Live PubMed search
Live results for "Phenibut (Ref) dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Phenibut (Ref) and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Phenibut (Ref) — clinical evidence
Live Scholar search
Cross-database citation index for Phenibut (Ref) as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.