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Supplements/Compound

Magnolol

Active magnolia biphenol.

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Overview

Active magnolia biphenol.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

GABA-A receptor modulator.

Pathways
  • · GABA-A receptor modulator

Effects on the body

Supports
Anxiolytic

Organ system effects

Brain & CNS

Magnolol modulates monoaminergic and GABAergic tone relevant to mood and anxiety regulation.

Evidence-based benefits

Anxiolytic

Moderate evidence

Potential side effects

Common
  • · Drowsiness
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Magnolol use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      200 mg
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Systematic reviewNeuropharmacology · 2009

      Magnolol pharmacology

      Lin YR, et al.

      Mechanistic review

      Key findings

      Anxiolytic without dependence.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — Anxiolytic

      Live PubMed search

      Live results for "Magnolol Anxiolytic" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "Anxiolytic". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — randomized controlled trial

      Live PubMed search

      Live results for "Magnolol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — meta-analysis

      Live PubMed search

      Live results for "Magnolol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — pharmacokinetics

      Live PubMed search

      Live results for "Magnolol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — safety adverse events

      Live PubMed search

      Live results for "Magnolol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Magnolol — dose response

      Live PubMed search

      Live results for "Magnolol dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Magnolol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Magnolol — clinical evidence

      Live Scholar search

      Cross-database citation index for Magnolol as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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