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evidence · mechanism · dose
Supplements/Compound

Uridine Monophosphate

Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.

MemoryMood EnhancementBrain & CognitiveNeuroprotection

Overview

Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.

Natural sources
    Common forms

      Mechanism of action

      Kennedy pathway substrate for phosphatidylcholine; upregulates D1/D2 receptor density.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improved cognition in stack with DHA + choline (TUMS)

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with
              • DHA + Choline
                TUMS stack for membrane synthesis.
              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              150–250 mg sublingual BID
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Uridine Mono…
              Amazon
              Wide selection · fast shipping
              Compound
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              iHerb
              Global delivery · curated brands
              Compound
              Uridine Mono…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              Systematic reviewBrain Res · 2010

              Uridine and brain phospholipid synthesis

              Wurtman RJ, et al.

              Review of uridine in CNS phospholipid synthesis.

              Key findings

              Increases synaptic membrane formation in preclinical/clinical work.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — Improved cognition in stack with DHA + choline

              Live PubMed search

              Live results for "Uridine Monophosphate Improved cognition in stack with DHA + choline" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "Improved cognition in stack with DHA + choline". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — randomized controlled trial

              Live PubMed search

              Live results for "Uridine Monophosphate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — meta-analysis

              Live PubMed search

              Live results for "Uridine Monophosphate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — pharmacokinetics

              Live PubMed search

              Live results for "Uridine Monophosphate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — safety adverse events

              Live PubMed search

              Live results for "Uridine Monophosphate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Uridine Monophosphate — dose response

              Live PubMed search

              Live results for "Uridine Monophosphate dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Uridine Monophosphate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Uridine Monophosphate — clinical evidence

              Live Scholar search

              Cross-database citation index for Uridine Monophosphate as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.