Overview
Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Kennedy pathway substrate for phosphatidylcholine; upregulates D1/D2 receptor density.
- · Kennedy pathway substrate for phosphatidylcholine
- · upregulates D1/D2 receptor density
Effects on the body
Organ system effects
Uridine Monophosphate acts on central nervous system targets implicated in attention, memory, and neuroprotection.
Evidence-based benefits
Improved cognition in stack with DHA + choline (TUMS)
Moderate evidencePotential side effects
- · Uridine Monophosphate is generally well-tolerated at evidence-based doses
- · Mild GI discomfort (nausea, loose stools, or bloating) possible at higher intakes
- · Headache or transient fatigue reported by a small fraction of users
- · Allergic or hypersensitivity reaction (rash, itching, swelling)
- · Sleep disturbance if taken late in the day
- · Discontinue and seek medical advice if symptoms are severe, persistent, or include difficulty breathing
Drug interactions
Supplement interactions
- DHA + CholineTUMS stack for membrane synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Uridine Monophosphate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Uridine Monophosphate third party tested NSF
CapsulesPre-measured Uridine Monophosphate capsules — easiest for travel and consistent daily dosing without scoops or scales.Uridine Monophosphate capsules
PowderBulk unflavored Uridine Monophosphate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Uridine Monophosphate powder unflavored
Best sellersMost-purchased Uridine Monophosphate products on Amazon — a quick way to see what's reviewed widely before you commit.Uridine Monophosphate best sellerScientific evidence8Show studiesHide studies
Uridine and brain phospholipid synthesis
Wurtman RJ, et al.
Review of uridine in CNS phospholipid synthesis.
Increases synaptic membrane formation in preclinical/clinical work.
PubMed: Uridine Monophosphate — Improved cognition in stack with DHA + choline
Live PubMed search
Live results for "Uridine Monophosphate Improved cognition in stack with DHA + choline" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "Improved cognition in stack with DHA + choline". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Uridine Monophosphate — randomized controlled trial
Live PubMed search
Live results for "Uridine Monophosphate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Uridine Monophosphate — meta-analysis
Live PubMed search
Live results for "Uridine Monophosphate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Uridine Monophosphate — pharmacokinetics
Live PubMed search
Live results for "Uridine Monophosphate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Uridine Monophosphate — safety adverse events
Live PubMed search
Live results for "Uridine Monophosphate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Uridine Monophosphate — dose response
Live PubMed search
Live results for "Uridine Monophosphate dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Uridine Monophosphate and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Uridine Monophosphate — clinical evidence
Live Scholar search
Cross-database citation index for Uridine Monophosphate as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.