Neuroprotection
Anti-oxidative and anti-inflammatory brain support.
Ranked by evidence strength across reported benefits.
Creatine Monohydrate
The most-studied and effective ergogenic aid — replenishes ATP via the phosphocreatine system.
Omega-3 (EPA/DHA)
Marine long-chain omega-3s — the most-studied anti-inflammatory and cardiovascular nutrient.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
Vitamin B12
Essential cobalamin for methylation, red blood cell formation, and myelin maintenance.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Caffeine
Adenosine antagonist with strong evidence for cognitive and physical performance.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Vitamin B1 (Thiamine)
Cofactor for carbohydrate metabolism and nerve conduction.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Methylfolate (L-5-MTHF)
Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.
Creatine Monohydrate
Gold-standard creatine form — the most studied supplement in sports science.
Mucuna Pruriens (Velvet Bean)
Natural L-DOPA source studied for Parkinson's, libido, and fertility.
Piracetam (Cognitive)
Original racetam used for cortical excitability disorders.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Methylcobalamin (B12)
Active methyl-form of B12 — directly usable in the methylation cycle.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Algal Omega-3 (Vegan EPA/DHA)
Plant-based EPA and DHA from microalgae for vegan diets.
Modafinil (Rx note)
Wakefulness-promoting Rx — listed for reference; not a supplement.
Choline Bitartrate
Affordable choline source — supports phospholipid synthesis and methylation.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory and recall after chronic dosing.
Omega-3 (rTG form)
Re-esterified triglyceride EPA/DHA — ~70% better absorption than ethyl ester form.
Algal Omega-3 (DHA/EPA)
Plant-source DHA (and some EPA) from cultivated marine algae — vegan alternative to fish oil.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Guanfacine (Ref)
α2A-agonist reference drug for prefrontal focus and ADHD.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
DHA (Prenatal)
Critical fatty acid for fetal brain and retinal development.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
L-Carnitine
Shuttles long-chain fatty acids into mitochondria for β-oxidation.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Curcumin
Yellow polyphenol from turmeric — anti-inflammatory and joint-supportive when properly bioavailable.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
Choline
Essential nutrient for cell membranes, methylation, and acetylcholine synthesis.
Panax Ginseng
Adaptogenic ginseng studied for fatigue, cognition, and erectile function.
American Ginseng
Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.
Mucuna Pruriens
Natural L-DOPA source studied for mood, libido, and Parkinson's.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Phosphatidylserine (PS)
Phospholipid that supports cognition and may blunt cortisol response to stress.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Salvia officinalis (Sage)
Culinary sage with cholinergic and anti-hyperhidrosis effects.
Alpha-GPC
Bioavailable choline source studied for cognition and acute power output.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Gotu Kola
Adaptogen used for cognitive support, anxiety, and wound healing.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
TUDCA (Tauroursodeoxycholic Acid)
Conjugated bile acid — hepatoprotective and ER-stress-reducing.
Citicoline (CDP-Choline)
Phospholipid precursor with cytidine bonus — supports membranes and dopamine.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
Ginkgo Biloba
Vasodilatory leaf extract for cognition and microcirculation.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
Krill Oil
Phospholipid-bound EPA/DHA from Antarctic krill — includes astaxanthin antioxidant.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
Kanna (Sceletium)
South African succulent acting as SSRI + PDE4 inhibitor for mood and stress.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
L-Tyrosine (Dopamine Replenishment)
Catecholamine precursor — replenishes dopamine/norepinephrine pools after stimulant use.
Vitamin B2 (Riboflavin)
FAD/FMN precursor central to redox reactions and migraine prophylaxis.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Piracetam
Original racetam; modulates AMPA receptors and membrane fluidity. Rx in many countries.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
Alpha-GPC (Cholinergic Recovery)
Choline source — supports acetylcholine after stimulant-driven depletion.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.
Huperzine A
Acetylcholinesterase inhibitor from club moss — potent cholinergic enhancer.
Uridine Monophosphate
Pyrimidine nucleoside — supports phosphatidylcholine synthesis and dopamine receptor density.
Riboflavin-5-Phosphate
Active form of B2 — used directly as FMN without liver conversion.
Benfotiamine
Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.
Curcumin Phytosome (Meriva)
Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Sulbutiamine
Lipid-soluble thiamine derivative crossing the BBB for fatigue and focus.
Vinpocetine
Periwinkle alkaloid that increases cerebral blood flow.
Bifidobacterium longum 1714
Psychobiotic strain shown to reduce stress and improve memory.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
Schisandra (Adaptogen)
Berry adaptogen for stress, focus, and liver protection.
Lemon Balm (Stress)
Melissa officinalis for acute stress and cognitive performance.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Urolithin A (Mitopure)
Gut-derived ellagitannin metabolite that induces mitophagy.
Creatine (Cognitive Dose)
Higher-dose creatine for cognitive performance under stress.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Citicoline (Cognition)
Intermediate in phosphatidylcholine synthesis; boosts focus.
Uridine Monophosphate
Pyrimidine that supports synaptic membrane synthesis.
Phosphatidylcholine (PC)
Major brain and hepatic phospholipid often given for liver support.
5-HTP (Mood Dose)
Serotonin precursor used for mild depression and migraine.
Rosemary (Cognitive)
Rosmarinus officinalis for memory and mood via inhalation or oral.
Yerba Mate (Focus)
Polyphenolic stimulant alternative to coffee for focus.
Panax Ginseng (Cognitive)
Asian ginseng (G115) studied for mental performance.
Rhodiola SHR-5 (Fatigue)
Adaptogen for stress-related fatigue and burnout.
Butterbur
Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.
Bacopa CDRI-08
Standardized Bacopa monnieri extract for memory.
Epitalon
Tetrapeptide that activates telomerase.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Selank
Russian anxiolytic peptide based on tuftsin.
Semax
Russian nootropic ACTH analog for cognitive enhancement.
Glycine + NAC (GlyNAC)
Glutathione-boosting combination for aging.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
MCT C8 (Caprylic Acid)
Pure C8 medium-chain triglyceride for ketone production.
Mucuna Pruriens
Velvet bean providing natural L-DOPA.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
L-Phenylalanine
Precursor to tyrosine and catecholamines.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Theracurmin
Nano-particle curcumin for bioavailability.
Luteolin
Flavone with anti-inflammatory effects.
Lion's Mane Erinacines
Hericium erinaceus mycelium for NGF.
Lion's Mane Fruiting Body
Hericinones-rich beta-glucan source.
CDP-Choline (Citicoline)
Phospholipid precursor for cognition.
Soy Lecithin
Phosphatidylcholine source.
Phosphatidylcholine
Membrane phospholipid for liver.
Suntheanine
Pharmaceutical-grade L-theanine.
Picamilon
Niacin-GABA conjugate.
Aniracetam
Fat-soluble racetam.
Oxiracetam
Racetam for cognition.
Allithiamine
Garlic-derived fat-soluble thiamine.
Folinic Acid (Leucovorin)
Reduced folate form.
Methylcobalamin High-Dose
Active B12 form for neuropathy.
CDP-Choline (Citicoline)-Stroke
Acute stroke neuroprotection.
Noopept (GVS-111)
Russian dipeptide nootropic.
DMAE (Dimethylaminoethanol)
Choline analog for cognition.
Pyritinol
Pyridoxine derivative for cognition.
Galantamine (Plant-Derived)
Snowdrop alkaloid AChE inhibitor.
Ginkgo Biloba EGb 761
Standardized Ginkgo for cognition.
Biotin (High-Dose)
High-dose for MS and hair.
Enzogenol
New Zealand pine bark extract.
Pycnogenol (Pine Bark)
French maritime pine bark for circulation.
Trans-Resveratrol
Active form of resveratrol.
Micronized Resveratrol
Improved bioavailability resveratrol.
Punicalagin
Major pomegranate ellagitannin.
Ellagic Acid
Ellagitannin hydrolysis product.
GOS (Galactooligosaccharides)
Galactose-based prebiotic.
6-Shogaol (Ginger)
Bioactive ginger compound.
Turmeric Essential Oil
Ar-turmerone for brain regeneration.
Longvida Curcumin
SLCP curcumin for brain bioavailability.
Lemon Balm Melissa Officinalis (Bluenesse)
Standardized Melissa for cognition.
Honokiol
Active magnolia compound.
Oleocanthal
EVOO ibuprofen-like compound.
DHA-Dominant Fish Oil
High-DHA for brain health.
Algae Omega-3
Vegan EPA/DHA source.
Salmon Roe Phospholipids
Phospholipid omega-3s from salmon eggs.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Quercetin
Flavonoid with antihistamine, anti-viral, and senolytic activity.
Noopept
Synthetic peptide with NGF/BDNF-raising activity at very low doses.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Cistanche Tubulosa
Desert plant tonic for libido and cognition.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Noopept
Synthetic dipeptide (peptide-like) studied for cognition and neuroprotection; not FDA approved.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Lion's Mane (Neuroregeneration)
NGF-upregulating mushroom — included in post-use stacks for neurotrophic support.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Spermidine
Polyamine that induces autophagy — emerging longevity supplement.
Pramiracetam
Racetam family — increases high-affinity choline uptake.
Liposomal Glutathione
Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.
S-Acetyl Glutathione
Acetylated GSH — stable through the gut and converted intracellularly to glutathione.
Agmatine Sulfate
Arginine metabolite with NMDA modulation and analgesic properties.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Phenylpiracetam Hydrazide
Hydrazide analog of phenylpiracetam reported to support memory and locomotion.
Coluracetam
Racetam acting on high-affinity choline uptake; studied for depression/anxiety.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Quercetin + Dasatinib (D+Q)
Reference senolytic combination cycled to clear senescent cells.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.
Noopept (High-Dose)
Russian dipeptide claimed to enhance BDNF and NGF.
Magnesium Acetyl-Taurate
Brain-penetrant Mg form combined with taurate for mood.