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evidence · mechanism · dose
Supplements/Compound

Phosphatidylserine (PS)

Phospholipid that supports cognition and may blunt cortisol response to stress.

Brain & CognitiveCortisol Management

Overview

Phospholipid that supports cognition and may blunt cortisol response to stress.

Natural sources
  • Soy lecithin (modern)
  • Bovine brain (historical)
Common forms
  • Soy PS
  • Sunflower PS

Mechanism of action

Membrane phospholipid; modulates HPA axis cortisol response.

Pathways
  • · Membrane phospholipid
  • · HPA modulation

Effects on the body

Supports
Cognition (elderly)
Decreases
Exercise-induced cortisol

Organ system effects

Brain & CNS

Improves cognition in age-related decline.

Evidence-based benefits

Improves cognition in age-related decline

Moderate evidence

Blunts cortisol response to acute stress

Moderate evidence

Potential side effects

Common
    Rare
    • · Insomnia
    Serious

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid / monitor with these medications
      • ·Alcohol, benzodiazepines, opioids, sedating antihistamines (additive CNS depression)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      100–300 mg/d

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      Phosphatidyl…
      Amazon
      Wide selection · fast shipping
      Compound
      Phosphatidyl…
      iHerb
      Global delivery · curated brands
      Compound
      Phosphatidyl…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (9)

      RCTNeurology · 1991

      Phosphatidylserine for age-associated memory impairment

      Crook TH, et al.

      12-week RCT of PS 300 mg/d in older adults with memory complaints.

      Key findings

      Improved memory performance vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — Improves cognition in age-related decline

      Live PubMed search

      Live results for "Phosphatidylserine (PS) Improves cognition in age-related decline" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "Improves cognition in age-related decline". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — Blunts cortisol response to acute stress

      Live PubMed search

      Live results for "Phosphatidylserine (PS) Blunts cortisol response to acute stress" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "Blunts cortisol response to acute stress". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — randomized controlled trial

      Live PubMed search

      Live results for "Phosphatidylserine (PS) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — meta-analysis

      Live PubMed search

      Live results for "Phosphatidylserine (PS) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — pharmacokinetics

      Live PubMed search

      Live results for "Phosphatidylserine (PS) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — safety adverse events

      Live PubMed search

      Live results for "Phosphatidylserine (PS) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Phosphatidylserine (PS) — dose response

      Live PubMed search

      Live results for "Phosphatidylserine (PS) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Phosphatidylserine (PS) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Phosphatidylserine (PS) — clinical evidence

      Live Scholar search

      Cross-database citation index for Phosphatidylserine (PS) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.