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evidence · mechanism · dose
Supplements/Herb

Mucuna Pruriens (Fertility)

L-DOPA-containing legume — improves sperm parameters and dopaminergic tone.

Male FertilitySperm HealthLibido SupportMood Enhancement

Overview

L-DOPA-containing legume — improves sperm parameters and dopaminergic tone.

Natural sources
    Common forms

      Mechanism of action

      Natural L-DOPA crosses BBB → dopamine; reduces oxidative stress in testes.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improved sperm count and motility

        Limited evidence

        Raises dopamine acutely

        Moderate evidence

        Potential side effects

        Common
        • · Nausea
        Rare
        • · Hypotension
        Serious

          Drug interactions

          MAOIs
          Hypertensive crisis.
          severe
          Antipsychotics
          Counteracts D2 blockade.
          moderate

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Avoid with these conditions
          • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
          Avoid / monitor with these medications
          • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          250–500 mg standardized to 15% L-DOPA
          With food?
          Optional

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Herb
          Mucuna Pruri…
          Amazon
          Wide selection · fast shipping
          Herb
          Mucuna Pruri…
          iHerb
          Global delivery · curated brands
          Herb
          Mucuna Pruri…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (9)

          RCTFertil Steril · 2009

          Mucuna pruriens in infertile men

          Shukla KK, et al.

          3-month RCT of mucuna in infertile men.

          Key findings

          Improved semen parameters and reduced oxidative stress.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — Improved sperm count and motility

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) Improved sperm count and motility" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "Improved sperm count and motility". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — Raises dopamine acutely

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) Raises dopamine acutely" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "Raises dopamine acutely". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — randomized controlled trial

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — meta-analysis

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — pharmacokinetics

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — safety adverse events

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Mucuna Pruriens (Fertility) — dose response

          Live PubMed search

          Live results for "Mucuna Pruriens (Fertility) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Mucuna Pruriens (Fertility) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Mucuna Pruriens (Fertility) — clinical evidence

          Live Scholar search

          Cross-database citation index for Mucuna Pruriens (Fertility) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.