Hormones & Endocrine
Testosterone, estrogen, thyroid, cortisol, insulin & growth hormone.
Ranked by evidence strength across reported benefits.
Magnesium
Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.
Ashwagandha
Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.
Vitamin D3
Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
Ginger
Culinary rhizome with strong antiemetic and anti-inflammatory effects.
Vitamin A (Retinol)
Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Psyllium Husk
Soluble fiber with strong evidence for cholesterol reduction and bowel regularity.
Psyllium Husk
Viscous soluble fiber — lowers cholesterol, glucose, and supports regularity.
Magnesium Glycinate
Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.
Saffron
Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Vitamin B6 (Pyridoxine)
Cofactor for >100 enzymes including neurotransmitter synthesis.
Folate (Vitamin B9)
One-carbon donor essential for DNA synthesis and neural tube development.
Iron
Oxygen-carrying mineral central to hemoglobin and cellular respiration.
Tribulus Terrestris
Traditionally used for libido; testosterone-boosting claims not supported by trials.
Chasteberry (Vitex)
Dopaminergic herb reducing prolactin and improving PMS/luteal phase symptoms.
Myo-Inositol
Insulin sensitizer used for PCOS and anxiety/OCD support.
Lactobacillus Probiotics
Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.
CBD (Cannabidiol)
Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Berberine (Glucose Use)
AMPK activator with metformin-comparable glucose-lowering effects.
Methylfolate (L-5-MTHF)
Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.
Glucomannan (Konjac)
Viscous soluble fiber that promotes satiety and lowers LDL.
Tribulus terrestris (Libido)
Steroidal saponin herb claimed for libido and sexual function.
Biotin (B7)
Coenzyme for carboxylases — popular for hair and nails despite weak data outside true deficiency.
Metformin (Rx, reference)
Diabetes drug studied for longevity (TAME trial) via AMPK activation.
Iodine
Halogen essential for thyroid hormone synthesis.
Copper
Trace mineral cofactor for ceruloplasmin and connective tissue crosslinking.
Bacopa Monnieri
Ayurvedic nootropic with strong evidence for memory consolidation over 8–12 weeks.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Selenium-Iodine Synergy (note)
See individual selenium and iodine entries; balance is critical for thyroid health.
Melatonin (low-dose physiologic)
Endogenous sleep hormone; low doses (0.3–0.5 mg) typically outperform mega-doses.
Iodine (Thyroid Optimization)
Essential thyroid hormone substrate — careful dosing required in autoimmunity.
Ferrous Sulfate
Standard low-cost iron salt — effective but commonly causes GI side effects.
Potassium Iodide
Standard inorganic iodine — thyroid hormone precursor and radioprotectant.
Lavender Oil (Silexan)
Oral lavender essential oil with proven anxiolytic effect.
Gotu Kola (Extra)
Standardized triterpenes for venous insufficiency and skin healing.
Marine Collagen (Extra)
Fish-derived type I collagen with high digestibility.
Psyllium (Extra Profile)
Viscous fiber with strong LDL-lowering effect.
Lugol's Iodine
Combined iodine/iodide solution used historically for thyroid support.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
DHA (Prenatal)
Critical fatty acid for fetal brain and retinal development.
Tesamorelin (Ref)
GHRH analog approved for HIV-associated visceral adiposity.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Copper Bisglycinate
Chelated copper used to balance high-dose zinc supplementation.
Kava (WS-1490)
Standardized kavalactone extract for anxiety.
Chamomile (GAD)
Matricaria recutita standardized extract for generalized anxiety.
Tongkat Ali
Malaysian root extract that frees bound testosterone via SHBG reduction.
Zinc
Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.
Berberine
Plant alkaloid that activates AMPK — metformin-like effects on glucose and lipids.
Maca
Andean root associated with libido improvement and energy without hormone changes.
Rhodiola Rosea
Arctic adaptogen — reduces fatigue and improves mental performance under stress.
Fenugreek
Spice/herb traditionally for libido & glycemic control; modest free-T effects.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
Collagen Peptides
Hydrolyzed protein supplying glycine, proline, and hydroxyproline for connective tissue.
Panax Ginseng
Adaptogenic ginseng studied for fatigue, cognition, and erectile function.
American Ginseng
Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.
Holy Basil (Tulsi)
Ayurvedic adaptogen with anti-stress, anti-inflammatory, and glycemic effects.
Mucuna Pruriens
Natural L-DOPA source studied for mood, libido, and Parkinson's.
Hyaluronic Acid
Glycosaminoglycan supporting skin hydration and joint lubrication.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Soy Isoflavones
Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.
Licorice Root
Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.
Phosphatidylserine (PS)
Phospholipid that supports cognition and may blunt cortisol response to stress.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Tongkat Ali (Eurycoma longifolia)
Malaysian root with moderate human evidence for raising free testosterone and reducing SHBG.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Myo-Inositol
Insulin-sensitizing sugar alcohol — first-line non-Rx option for PCOS.
Yohimbine
Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.
Phosphatidylserine
Membrane phospholipid — blunts cortisol response to stress and exercise.
KSM-66 Ashwagandha
Root-only standardized ashwagandha extract — the most-studied form for stress and T-support.
Verisol® Collagen Peptides
Specific bovine peptide blend marketed for skin and cellulite.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Salvia officinalis (Sage)
Culinary sage with cholinergic and anti-hyperhidrosis effects.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
Passionflower
Mild anxiolytic and sleep aid with GABA-A modulation.
Gotu Kola
Adaptogen used for cognitive support, anxiety, and wound healing.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
DIM (Diindolylmethane)
Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.
Saw Palmetto
5α-reductase-inhibiting berry extract — used for BPH and androgenic hair loss.
MSM (Methylsulfonylmethane)
Bioavailable sulfur donor for joints, skin, and hair-keratin synthesis.
Marine Collagen Peptides
Hydrolyzed fish collagen — supplies glycine, proline, and bioactive di/tripeptides for skin and hair.
DIM (Diindolylmethane)
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
Chasteberry (Vitex)
Dopaminergic herb that lowers prolactin and supports luteal-phase progesterone.
L-Arginine (GH Pulse)
Stimulates a transient growth hormone pulse when taken on an empty stomach.
Maca (Lepidium meyenii)
Andean root traditionally used for libido and fertility — non-hormonal mechanism.
Rhodiola Rosea
Arctic adaptogen for mental fatigue, burnout, and stress resilience.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
P-5-P (Pyridoxal-5-Phosphate)
Active coenzyme form of B6 — preferred over pyridoxine HCl for sensitive populations.
Niacinamide
Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.
Biotin (Hair Dose)
B-vitamin used cosmetically for hair and nail growth.
Passionflower (Anxiety)
Passiflora incarnata for mild GAD and pre-surgical anxiety.
Calcium
Major bone mineral; also critical for muscle contraction and nerve signaling.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
L-Tyrosine
Catecholamine precursor preserving cognition under stress and sleep deprivation.
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
Chamomile
Gentle anxiolytic and sleep-supportive herb.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Schisandra
Adaptogenic berry traditionally used for stamina, liver protection, and stress resilience.
Olive Leaf Extract
Mediterranean herb with antihypertensive and immune effects.
Saw Palmetto
Lipidosterolic extract used for BPH urinary symptoms.
Pygeum
African plum bark used for BPH urinary symptoms.
Stinging Nettle Root
Herbal for BPH and SHBG modulation, often paired with saw palmetto.
Black Cohosh
Standardized extract for menopausal vasomotor symptoms.
Spearmint Tea
Used for hirsutism in PCOS via mild anti-androgen effect.
Cinnamon
Common spice with modest glucose-lowering effects (cassia type studied most).
Gymnema Sylvestre
Herb that blocks sweet taste perception and modestly lowers glucose.
GHK-Cu (Copper Peptide)
Copper-binding tripeptide used topically for skin remodeling.
Magnesium Glycinate
Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.
Cranberry
Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.
D-Mannose
Simple sugar that binds E. coli fimbriae, flushing them from the urinary tract.
Black Cohosh
Phytotherapy for menopausal vasomotor symptoms — non-estrogenic but symptom-active.
D-Chiro-Inositol
Complementary inositol used in 40:1 myo-inositol ratio for PCOS.
L-Tyrosine (Thyroid Substrate)
Amino acid substrate paired with iodine to form thyroid hormones.
Panax Ginseng (Sexual Health)
Korean red ginseng with RCT-level evidence for erectile dysfunction.
Zinc (Sperm Health)
Concentrated in semen — essential for sperm production and testosterone.
Glycine (Sleep Onset)
3 g pre-bed lowers core body temperature and improves subjective sleep.
Ashwagandha (Cortisol Lowering)
Validated cortisol-lowering adaptogen — ~28% reduction in chronically stressed adults.
Holy Basil (Tulsi)
Sacred basil adaptogen — anti-stress and mild glucose-lowering effects.
Benfotiamine
Lipid-soluble thiamine derivative with superior tissue penetration — used in diabetic neuropathy.
Iron Bisglycinate
Chelated ferrous iron — best-tolerated form with high absorption and minimal GI distress.
Sensoril Ashwagandha
Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Magnolia Bark
GABAergic anxiolytic bark extract used for sleep and stress.
Hops Extract
Bitter cone extract with mild sedative and phytoestrogenic effects.
Tongkat Ali (Physta)
Water-extracted standardized tongkat ali for testosterone and stress.
Icariin (Horny Goat Weed)
Active flavonoid from Epimedium acting as PDE5 inhibitor.
Olive Leaf Extract
Polyphenol-rich leaf extract for blood pressure and glucose.
Lycopene
Tomato carotenoid linked with prostate and cardiovascular protection.
Akkermansia muciniphila
Mucin-degrading commensal linked to metabolic health.
Maitake D-Fraction
Standardized β-glucan from Grifola frondosa for immune support.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
White Kidney Bean Extract
α-amylase inhibitor that lowers post-meal carbohydrate absorption.
Ashwagandha (Strength)
KSM-66 dose for resistance training adaptations.
Vanadyl Sulfate
Trace mineral with insulin-mimetic effects studied for T2DM.
Centella asiatica (Skin)
Standardized titrated extract for scars and venous skin changes.
Stevia (Rebaudioside A)
Non-caloric sweetener that may improve glycemia and BP.
MK-677 (Ibutamoren) — Ref
Oral ghrelin mimetic that raises GH/IGF-1 (research reference).
Ipamorelin (Ref)
Selective GHRP-2 analog with minimal cortisol/prolactin effect.
Glycine (Collagen Stack)
Free-form glycine paired with collagen for connective tissue synthesis.
Zinc Bisglycinate (High-Bio)
Chelated zinc with superior absorption and tolerability.
Boron (Extra)
Trace mineral that modulates steroid hormones and bone.
Choline-Stabilized Orthosilicic Acid (ch-OSA)
Highly bioavailable silica for hair, skin, and bone.
L-Tryptophan (Sleep)
Direct serotonin/melatonin precursor for nocturnal use.
GABA (Pharma-grade)
Fermented GABA with reported peripheral relaxation effects.
Valerian (Sleep)
Valeriana officinalis root extract for sleep latency.
Holy Basil (Tulsi)
Adaptogenic basil used for stress and blood sugar.
Shilajit (Fulvic-Standardized)
Himalayan mineral pitch with fulvic acids studied for testosterone.
California Poppy
Eschscholzia californica for anxiety and insomnia.
Centella Triterpene Fraction
Standardized madecassoside/asiaticoside for skin and venous health.
TB-500 (Thymosin Beta-4)
Synthetic thymosin fragment for tissue repair.
Myo-Inositol
Insulin sensitizer for PCOS and metabolic health.
Shoden Ashwagandha
35% withanolide glycoside Ashwagandha for sleep.
Mucuna Pruriens
Velvet bean providing natural L-DOPA.
Squalene
Olive oil/shark liver lipid antioxidant.
L-Lysine
Essential amino acid for collagen and HSV prevention.
Bamboo Silica
Plant-based silicon for skin and bones.
Choline-Stabilized OSA
Bioavailable silicon form.
Potassium Iodide
Iodine source for thyroid hormone.
Lugol's Iodine
Strong iodine solution.
Kelp Iodine
Brown seaweed iodine source.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Astaxanthin (Haematococcus)
Algae carotenoid antioxidant.
Nettle Root
Urtica dioica for BPH.
Beta-Sitosterol
Plant sterol for BPH and cholesterol.
Black Maca
Lepidium meyenii black variant for energy.
Red Maca
Lepidium meyenii red variant for prostate.
Chaste Tree (Vitex)
Vitex agnus-castus for PMS.
Genistein
Soy isoflavone with bone benefits.
S-Equol
Daidzein metabolite for menopause.
Poria Cocos
TCM mushroom for sleep and immunity.
Tremella Fuciformis
Snow fungus for skin hydration.
PharmaGABA
Naturally fermented GABA.
DMAE (Dimethylaminoethanol)
Choline analog for cognition.
Type III Collagen
Skin and vascular collagen.
Marine Collagen Peptides
Fish-derived collagen.
Bovine Collagen Peptides
Cow-derived collagen hydrolysate.
Hyaluronic Acid (Oral)
Oral HA for skin and joints.
OptiMSM
Distilled MSM for joints.
Biotin (High-Dose)
High-dose for MS and hair.
MSM (Methylsulfonylmethane)
Organic sulfur for joints and skin.
Grape Seed Extract
Vitis vinifera procyanidins.
Pomegranate Extract
Punica granatum ellagitannins.
Cranberry Extract
Vaccinium macrocarpon for UTI prevention.
Royal Jelly
Queen bee secretion with 10-HDA.
Manuka Honey
Leptospermum honey with MGO.
Tongkat Ali Eurycomanone-Standardized
LJ100 standardized to 22% eurypeptides.
Stinging Nettle Root
Urtica dioica root for free testosterone.
Boron Citrate
Boron for hormone modulation.
Zinc Monomethionine (ZMA)
Zinc + magnesium + B6 for recovery.
KSM-66 Ashwagandha Thyroid
Ashwagandha for subclinical hypothyroid.
Bladderwrack
Fucus vesiculosus seaweed for thyroid.
Saffron Affron
Standardized saffron for mood.
Valerian Root Extract
Valeriana officinalis for sleep.
Valerian + Hops
Sleep blend.
Honokiol
Active magnolia compound.
Liposomal Vitamin C
Phospholipid-encapsulated vitamin C.
Ascorbyl Palmitate
Fat-soluble vitamin C ester.
Micellar Casein
Slow-digesting milk protein.
Evening Primrose Oil
GLA omega-6 for skin and PMS.
Borage Oil
Highest GLA content.
Blackcurrant Seed Oil
GLA + ALA omega-3/6.
Hemp Seed Oil
3:1 omega-6 to omega-3 ratio.
Vitamin B7 (Biotin)
Carboxylase cofactor marketed for hair, skin, and nail support.
Chromium
Trace mineral marketed for blood sugar control and carbohydrate cravings.
Boron
Trace mineral implicated in steroid hormone metabolism and bone integrity.
5-HTP
Direct serotonin precursor with mood and sleep applications.
Eleuthero
Adaptogen used to support stamina, immune function, and stress resilience.
Evening Primrose Oil
Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
Pumpkin Seed Oil
Cold-pressed seed oil studied for hair density and prostate health.
Boron
Trace mineral with modest effects on free testosterone and bone mineralization.
Shatavari
Ayurvedic adaptogen used for female hormone balance and lactation support.
Gymnema Sylvestre
Sugar-blocking herb (gymnemic acid) used for cravings and post-prandial glucose.
Guggul (Commiphora mukul)
Ayurvedic resin used historically for cholesterol and thyroid support.
Magnesium Taurate
Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.
Cistanche Tubulosa
Desert plant tonic for libido and cognition.
Fadogia Agrestis
Nigerian shrub — popularized for testosterone support; sparse human data.
Vitamin B5 (Pantothenic acid)
Component of coenzyme A, central to fatty acid and acetylcholine synthesis.
Silica (Silicon)
Trace element involved in collagen and connective tissue crosslinking.
GABA
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Valerian Root
Sedative herb traditionally used for sleep onset and mild anxiety.
Horny Goat Weed
PDE5-inhibiting flavonoid (icariin) used for libido and erectile support.
Tongkat Ali (LJ100)
See main Tongkat Ali entry — kept here as placeholder, removed.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Calcium D-Glucarate
Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.
Dong Quai
TCM herb traditionally used for menstrual and menopausal symptoms.
Red Clover
Isoflavone-rich legume traditionally used for menopausal symptoms.
Bitter Melon
Traditional anti-diabetic; modest glucose-lowering and weight-loss effects.
Phenibut (caution)
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
Uva-Ursi
Antibacterial herb for acute uncomplicated UTI; alkaline urine required.
Rosemary Oil (Topical)
Topical rosemary oil — comparable to 2% minoxidil for AGA in head-to-head trial.
Horsetail Extract
Silica-rich herb traditionally used for hair, nail, and connective tissue support.
Marine Protein Complex (AminoMar)
Proprietary marine-derived complex (AminoMar) clinically studied for thinning hair in women.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Calcium-D-Glucarate
Inhibits β-glucuronidase to support estrogen and toxin elimination via the liver.
Bitter Melon
Plant insulin analog (charantin, polypeptide-p) for glycemic control.
Ashwagandha (Thyroid Support)
Supports T4→T3 conversion in subclinical hypothyroid adults.
L-Ornithine
Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.
Horny Goat Weed (Epimedium)
Icariin-rich herb with PDE5-inhibitor-like activity for erectile function.
Valerian Root
GABAergic sedative herb — modest sleep onset benefit.
Zinc Picolinate
Zinc chelated to picolinic acid — one of the most bioavailable oral forms.
Zinc Bisglycinate
Glycine-chelated zinc — high absorption and very gentle on the stomach.
California Poppy
Mild sedative with anxiolytic and analgesic activity.
Ziziphus (Jujube Seed)
Traditional Chinese seed extract for insomnia and anxiety.
Pine Pollen
Phyto-androgen pollen containing trace testosterone and DHEA.
Biotinyl Tripeptide-1 (Procapil)
Topical peptide complex marketed for hair anchoring.
Topical Saw Palmetto
Topical lotion form for androgenetic alopecia.
Dihydroberberine
Reduced form of berberine with 5× greater oral bioavailability.
Fadogia Agrestis
African shrub touted for testosterone (rodent data only).
Fadogia Agrestis
African shrub popularized for testosterone; limited human data and toxicology concerns.