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Supplements/Peptide

TB-500 (Thymosin Beta-4)

Synthetic thymosin fragment for tissue repair.

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Overview

Synthetic thymosin fragment for tissue repair.

Natural sources
  • Synthetic peptide manufactured to pharmaceutical or research-grade purity
  • Subcutaneous injection, sublingual, or oral preparation depending on bioavailability
  • Compounded by a licensed pharmacy for clinical use
Common forms
  • Subcutaneous injection
  • Oral or sublingual lozenge
  • Nasal spray
  • Compounded topical

Mechanism of action

Sequesters G-actin, promotes angiogenesis and cell migration.

Pathways
  • · Sequesters G-actin, promotes angiogenesis
  • · cell migration

Effects on the body

Supports
Accelerates wound healing

Organ system effects

Skin

TB-500 (Thymosin Beta-4) supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Evidence-based benefits

Accelerates wound healing

Moderate evidence

Potential side effects

Common
  • · Injection site pain
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose TB-500 (Thymosin Beta-4) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with
      • Collagen peptides
        Provides amino acid substrate for connective tissue synthesis.
      • Vitamin C
        Required cofactor for collagen hydroxylation.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2 mg subcutaneous twice weekly
      Best form
      Most evidence is based on the subcutaneous injection form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Either with or without food.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      AnimalJ Invest Dermatol · 1999

      Thymosin beta-4 in wound healing

      Malinda KM, et al.

      Rat wound model

      Key findings

      Accelerated wound closure 42%.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — Accelerates wound healing

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) Accelerates wound healing" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "Accelerates wound healing". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — randomized controlled trial

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — meta-analysis

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — pharmacokinetics

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — safety adverse events

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: TB-500 (Thymosin Beta-4) — dose response

      Live PubMed search

      Live results for "TB-500 (Thymosin Beta-4) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching TB-500 (Thymosin Beta-4) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: TB-500 (Thymosin Beta-4) — clinical evidence

      Live Scholar search

      Cross-database citation index for TB-500 (Thymosin Beta-4) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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