Overview
Chelated copper used to balance high-dose zinc supplementation.
- Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
- Fortified foods such as cereals, breads, plant milks, and table salt
- Mineral supplements as chelates, citrates, glycinates, or inorganic salts
- Chelated form (glycinate, bisglycinate, citrate, malate)
- Inorganic salt (oxide, sulfate, chloride)
- Liquid ionic solution
- Topical or transdermal preparation
Mechanism of action
Cofactor for SOD1, lysyl oxidase, and ceruloplasmin.
- · Cofactor for SOD1, lysyl oxidase
- · and ceruloplasmin
Effects on the body
Organ system effects
Copper Bisglycinate supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.
Evidence-based benefits
Prevents zinc-induced copper deficiency
Strong evidencePotential side effects
- · Nausea at high dose
Drug interactions
Supplement interactions
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Copper Bisglycinate — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Copper Bisglycinate third party tested NSF
CapsulesPre-measured Copper Bisglycinate capsules — easiest for travel and consistent daily dosing without scoops or scales.Copper Bisglycinate capsules
PowderBulk unflavored Copper Bisglycinate powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Copper Bisglycinate powder unflavored
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Zinc-induced copper deficiency
Willis MS, et al.
Case series of zinc-overdose patients.
Reversed with copper repletion.
PubMed: Copper Bisglycinate — Prevents zinc-induced copper deficiency
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