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evidence · mechanism · dose
Supplements/Mineral

Copper Bisglycinate

Chelated copper used to balance high-dose zinc supplementation.

General WellnessSkin, Hair & Nails

Overview

Chelated copper used to balance high-dose zinc supplementation.

Natural sources
    Common forms

      Mechanism of action

      Cofactor for SOD1, lysyl oxidase, and ceruloplasmin.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Prevents zinc-induced copper deficiency

        Strong evidence

        Potential side effects

        Common
          Rare
          • · Nausea at high dose
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            1–2 mg
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Mineral
            Copper Bisgl…
            Amazon
            Wide selection · fast shipping
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            iHerb
            Global delivery · curated brands
            Mineral
            Copper Bisgl…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortAm J Clin Pathol · 2005

            Zinc-induced copper deficiency

            Willis MS, et al.

            Case series of zinc-overdose patients.

            Key findings

            Reversed with copper repletion.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — Prevents zinc-induced copper deficiency

            Live PubMed search

            Live results for "Copper Bisglycinate Prevents zinc-induced copper deficiency" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "Prevents zinc-induced copper deficiency". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — randomized controlled trial

            Live PubMed search

            Live results for "Copper Bisglycinate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — meta-analysis

            Live PubMed search

            Live results for "Copper Bisglycinate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — pharmacokinetics

            Live PubMed search

            Live results for "Copper Bisglycinate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — safety adverse events

            Live PubMed search

            Live results for "Copper Bisglycinate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Copper Bisglycinate — dose response

            Live PubMed search

            Live results for "Copper Bisglycinate dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Copper Bisglycinate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Copper Bisglycinate — clinical evidence

            Live Scholar search

            Cross-database citation index for Copper Bisglycinate as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.