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evidence · mechanism · dose
Supplements/Compound

MK-677 (Ibutamoren) — Ref

Oral ghrelin mimetic that raises GH/IGF-1 (research reference).

Growth Hormone SupportMuscle Growth

Overview

Oral ghrelin mimetic that raises GH/IGF-1 (research reference).

Natural sources
    Common forms

      Mechanism of action

      Ghrelin receptor agonism stimulates pulsatile GH release.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases lean mass in elderly

        Moderate evidence

        Potential side effects

        Common
        • · Edema
        • · Increased appetite
        Rare
        • · CHF in frail patients
        Serious
        • · Insulin resistance

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        Research only

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
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        Global delivery · curated brands
        Compound
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        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        RCTAnn Intern Med · 2008

        MK-677 in frail elderly

        Nass R, et al.

        1-year DB-RCT in 65 frail elderly.

        Key findings

        MK-677 raised IGF-1 to young-adult range and increased lean mass.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — Increases lean mass in elderly

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref Increases lean mass in elderly" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "Increases lean mass in elderly". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — randomized controlled trial

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — meta-analysis

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — pharmacokinetics

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — safety adverse events

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: MK-677 (Ibutamoren) — Ref — dose response

        Live PubMed search

        Live results for "MK-677 (Ibutamoren) — Ref dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching MK-677 (Ibutamoren) — Ref and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: MK-677 (Ibutamoren) — Ref — clinical evidence

        Live Scholar search

        Cross-database citation index for MK-677 (Ibutamoren) — Ref as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.