Overview
Oral ghrelin mimetic that raises GH/IGF-1 (research reference).
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Ghrelin receptor agonism stimulates pulsatile GH release.
- · Ghrelin receptor agonism stimulates pulsatile GH release
Effects on the body
Organ system effects
MK-677 (Ibutamoren) — Ref influences muscle protein synthesis, neuromuscular output, or recovery from exercise.
Evidence-based benefits
Increases lean mass in elderly
Moderate evidencePotential side effects
- · Edema
- · Increased appetite
- · CHF in frail patients
- · Insulin resistance
Drug interactions
Supplement interactions
- Creatine monohydrateFoundational support for strength, power, and lean mass.
- Whey or EAAsProvides amino acid substrate for muscle protein synthesis.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified MK-677 (Ibutamoren) — Ref — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.MK-677 (Ibutamoren) — Ref third party tested NSF
CapsulesPre-measured MK-677 (Ibutamoren) — Ref capsules — easiest for travel and consistent daily dosing without scoops or scales.MK-677 (Ibutamoren) — Ref capsules
PowderBulk unflavored MK-677 (Ibutamoren) — Ref powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.MK-677 (Ibutamoren) — Ref powder unflavored
Best sellersMost-purchased MK-677 (Ibutamoren) — Ref products on Amazon — a quick way to see what's reviewed widely before you commit.MK-677 (Ibutamoren) — Ref best sellerScientific evidence8Show studiesHide studies
MK-677 in frail elderly
Nass R, et al.
1-year DB-RCT in 65 frail elderly.
MK-677 raised IGF-1 to young-adult range and increased lean mass.
PubMed: MK-677 (Ibutamoren) — Ref — Increases lean mass in elderly
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PubMed: MK-677 (Ibutamoren) — Ref — randomized controlled trial
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Google Scholar: MK-677 (Ibutamoren) — Ref — clinical evidence
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