Growth Hormone Support
Natural GH/IGF-1 modulation.
Ranked by evidence strength across reported benefits.
Magnesium
Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.
Ashwagandha
Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.
Vitamin D3
Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
L-Theanine
Calm focus — alpha-wave amino acid from green tea that takes the edge off caffeine.
Magnesium Glycinate
Chelated magnesium bound to glycine — best-tolerated form for sleep, calm, and muscle relaxation.
Chasteberry (Vitex)
Dopaminergic herb reducing prolactin and improving PMS/luteal phase symptoms.
CBD (Cannabidiol)
Non-intoxicating cannabinoid studied for anxiety, sleep, and seizures.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Iodine
Halogen essential for thyroid hormone synthesis.
Selenium-Iodine Synergy (note)
See individual selenium and iodine entries; balance is critical for thyroid health.
Melatonin (low-dose physiologic)
Endogenous sleep hormone; low doses (0.3–0.5 mg) typically outperform mega-doses.
Iodine (Thyroid Optimization)
Essential thyroid hormone substrate — careful dosing required in autoimmunity.
Potassium Iodide
Standard inorganic iodine — thyroid hormone precursor and radioprotectant.
Lavender Oil (Silexan)
Oral lavender essential oil with proven anxiolytic effect.
Tesamorelin (Ref)
GHRH analog approved for HIV-associated visceral adiposity.
Kava (WS-1490)
Standardized kavalactone extract for anxiety.
Chamomile (GAD)
Matricaria recutita standardized extract for generalized anxiety.
Tongkat Ali
Malaysian root extract that frees bound testosterone via SHBG reduction.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
KSM-66 Ashwagandha
Root-only standardized ashwagandha extract — the most-studied form for stress and T-support.
Passionflower
Mild anxiolytic and sleep aid with GABA-A modulation.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
DIM (Diindolylmethane)
Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.
DIM (Diindolylmethane)
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
L-Arginine (GH Pulse)
Stimulates a transient growth hormone pulse when taken on an empty stomach.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
Passionflower (Anxiety)
Passiflora incarnata for mild GAD and pre-surgical anxiety.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
L-Tryptophan
Essential amino acid precursor to serotonin and melatonin.
Chamomile
Gentle anxiolytic and sleep-supportive herb.
Lemon Balm
Mild anxiolytic with cognitive calming effects via GABA-T inhibition.
Saw Palmetto
Lipidosterolic extract used for BPH urinary symptoms.
Stinging Nettle Root
Herbal for BPH and SHBG modulation, often paired with saw palmetto.
Magnesium Glycinate
Bisglycinate chelate form of magnesium — gentle, well-absorbed, ideal for sleep.
Glycine (Sleep Onset)
3 g pre-bed lowers core body temperature and improves subjective sleep.
Sensoril Ashwagandha
Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Magnolia Bark
GABAergic anxiolytic bark extract used for sleep and stress.
Hops Extract
Bitter cone extract with mild sedative and phytoestrogenic effects.
MK-677 (Ibutamoren) — Ref
Oral ghrelin mimetic that raises GH/IGF-1 (research reference).
Ipamorelin (Ref)
Selective GHRP-2 analog with minimal cortisol/prolactin effect.
L-Tryptophan (Sleep)
Direct serotonin/melatonin precursor for nocturnal use.
GABA (Pharma-grade)
Fermented GABA with reported peripheral relaxation effects.
Valerian (Sleep)
Valeriana officinalis root extract for sleep latency.
California Poppy
Eschscholzia californica for anxiety and insomnia.
Shoden Ashwagandha
35% withanolide glycoside Ashwagandha for sleep.
Poria Cocos
TCM mushroom for sleep and immunity.
PharmaGABA
Naturally fermented GABA.
Zinc Monomethionine (ZMA)
Zinc + magnesium + B6 for recovery.
Saffron Affron
Standardized saffron for mood.
Valerian Root Extract
Valeriana officinalis for sleep.
Valerian + Hops
Sleep blend.
Honokiol
Active magnolia compound.
Micellar Casein
Slow-digesting milk protein.
Boron
Trace mineral implicated in steroid hormone metabolism and bone integrity.
5-HTP
Direct serotonin precursor with mood and sleep applications.
Magnesium Taurate
Magnesium + taurine — gentle on the gut with cardiovascular and glycemic synergies.
GABA
Primary inhibitory neurotransmitter; oral supplementation has limited CNS penetration.
Valerian Root
Sedative herb traditionally used for sleep onset and mild anxiety.
Pregnenolone
Master steroid precursor; small doses studied for cognition and PTSD.
Calcium D-Glucarate
Beta-glucuronidase inhibitor promoting elimination of conjugated hormones/toxins.
Phenibut (caution)
GABA-B agonist with high abuse and dependence potential; restricted in many countries.
Magnesium L-Threonate
Mg form designed for brain penetration; studied for cognition and sleep.
Calcium-D-Glucarate
Inhibits β-glucuronidase to support estrogen and toxin elimination via the liver.
Ashwagandha (Thyroid Support)
Supports T4→T3 conversion in subclinical hypothyroid adults.
L-Ornithine
Urea-cycle amino acid that lowers fatigue and supports nighttime GH release.
Valerian Root
GABAergic sedative herb — modest sleep onset benefit.
California Poppy
Mild sedative with anxiolytic and analgesic activity.
Ziziphus (Jujube Seed)
Traditional Chinese seed extract for insomnia and anxiety.