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evidence · mechanism · dose
Supplements/Peptide

Ipamorelin (Ref)

Selective GHRP-2 analog with minimal cortisol/prolactin effect.

Growth Hormone SupportAthletic Performance

Overview

Selective GHRP-2 analog with minimal cortisol/prolactin effect.

Natural sources
    Common forms

      Forms & variants of Ipamorelin

      Different chemical forms of Ipamorelin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Ipamorelin

      Selective GH secretagogue researched for muscle and recovery; not FDA approved.

      Mechanism of action

      Selective ghrelin receptor agonism on pituitary somatotrophs.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases GH release without prolactin/cortisol rise

        Moderate evidence

        Potential side effects

        Common
        • · Flush
        • · Headache
        Rare
          Serious
          • · Not FDA-approved for any indication

          Drug interactions

          No notable interactions reported.

          Safety & non-supplemental interactions

          Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

          Avoid if you are
          • ·Pregnant or breastfeeding (insufficient safety data)
          • ·Children under 18 (unless directed by a clinician)
          Other notes
          • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

          Supplement interactions

          Pairs well with

          None listed.

          Avoid combining with

          No specific avoidances listed.

          Dosing & bioavailability

          Typical dose
          Research only

          Where to buy

          Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

          Peptide
          Ipamorelin (…
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          iHerb
          Global delivery · curated brands
          Peptide
          Ipamorelin (…
          Thorne
          Practitioner-grade · NSF tested

          Scientific evidence (8)

          CohortEur J Endocrinol · 1998

          Ipamorelin selectivity in humans

          Raun K, et al.

          Healthy volunteer study.

          Key findings

          Increased GH selectively without raising prolactin/cortisol.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — Increases GH release without prolactin/cortisol rise

          Live PubMed search

          Live results for "Ipamorelin (Ref) Increases GH release without prolactin/cortisol rise" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "Increases GH release without prolactin/cortisol rise". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — randomized controlled trial

          Live PubMed search

          Live results for "Ipamorelin (Ref) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — meta-analysis

          Live PubMed search

          Live results for "Ipamorelin (Ref) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — pharmacokinetics

          Live PubMed search

          Live results for "Ipamorelin (Ref) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — safety adverse events

          Live PubMed search

          Live results for "Ipamorelin (Ref) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewPubMed (NLM) · 1970

          PubMed: Ipamorelin (Ref) — dose response

          Live PubMed search

          Live results for "Ipamorelin (Ref) dose response" across the PubMed/MEDLINE peer-reviewed index.

          Key findings

          Opens current human and preclinical literature matching Ipamorelin (Ref) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

          Open study
          Systematic reviewGoogle Scholar · 1970

          Google Scholar: Ipamorelin (Ref) — clinical evidence

          Live Scholar search

          Cross-database citation index for Ipamorelin (Ref) as it relates to "clinical evidence".

          Key findings

          Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

          Open study
          Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.