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evidence · mechanism · dose
Supplements/Peptide

Ipamorelin

Selective GH secretagogue researched for muscle and recovery; not FDA approved.

Muscle GrowthRecovery Optimization

Overview

Selective GH secretagogue researched for muscle and recovery; not FDA approved.

Natural sources
  • Synthetic peptide
Common forms
  • Injectable

Forms & variants of Ipamorelin

Different chemical forms of Ipamorelin behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Pulsatile dose
Ipamorelin (Ref)

Selective GHRP-2 analog with minimal cortisol/prolactin effect.

Mechanism of action

Ghrelin receptor agonist that selectively releases GH without cortisol/prolactin rise.

Pathways
  • · GHRH-independent GH release

Effects on the body

Increases
GH pulse

Organ system effects

Endocrine

Mimics natural GH pulse.

Evidence-based benefits

Increases GH/IGF-1

Moderate evidence

Functional outcomes need study

Limited evidence

Potential side effects

Common
  • · Injection site reactions
Rare
    Serious
    • · WADA banned
    • · Edema
    • · Insulin resistance (high doses)

    Drug interactions

    Corticosteroids
    Blunt GH effect.
    moderate

    Safety & non-supplemental interactions

    Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

    Avoid if you are
    • ·Pregnant or breastfeeding (insufficient safety data)
    • ·Children under 18 (unless directed by a clinician)
    Other notes
    • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with
    • Athletes (banned)
      WADA Prohibited List.

    Dosing & bioavailability

    Typical dose
    Investigational

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Peptide
    Ipamorelin
    Amazon
    Wide selection · fast shipping
    Peptide
    Ipamorelin
    iHerb
    Global delivery · curated brands
    Peptide
    Ipamorelin
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (9)

    AnimalEur J Endocrinol · 1998

    Ghrelin-receptor agonists on growth hormone secretion

    Raun K, et al.

    Preclinical study of ipamorelin on GH release.

    Key findings

    Selective GH release without cortisol/prolactin elevation.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — Increases GH/IGF-1

    Live PubMed search

    Live results for "Ipamorelin Increases GH/IGF-1" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "Increases GH/IGF-1". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — Functional outcomes need study

    Live PubMed search

    Live results for "Ipamorelin Functional outcomes need study" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "Functional outcomes need study". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — randomized controlled trial

    Live PubMed search

    Live results for "Ipamorelin randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — meta-analysis

    Live PubMed search

    Live results for "Ipamorelin meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — pharmacokinetics

    Live PubMed search

    Live results for "Ipamorelin pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — safety adverse events

    Live PubMed search

    Live results for "Ipamorelin safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Ipamorelin — dose response

    Live PubMed search

    Live results for "Ipamorelin dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Ipamorelin and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Ipamorelin — clinical evidence

    Live Scholar search

    Cross-database citation index for Ipamorelin as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.