Overview
Stimulates a transient growth hormone pulse when taken on an empty stomach.
Mechanism of action
Inhibits somatostatin → unmasks endogenous GH pulse from the pituitary; NO synthesis substrate.
- · Somatostatin suppression
- · NOS substrate
Effects on the body
Organ system effects
Evidence-based benefits
Acutely raises GH (5–10 g oral)
Moderate evidenceModest BP and ED improvement
Limited evidencePotential side effects
- · GI upset
- · Herpes reactivation (high dose)
Drug interactions
No notable interactions reported.
Supplement interactions
None listed.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Scientific evidence (9)
L-arginine on growth hormone secretion
Kanaley JA
Review of arginine on resting and exercise-induced GH.
Resting GH increases; blunts exercise-induced GH rise.
PubMed: L-Arginine (GH Pulse) — Acutely raises GH
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PubMed: L-Arginine (GH Pulse) — Modest BP and ED improvement
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PubMed: L-Arginine (GH Pulse) — randomized controlled trial
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PubMed: L-Arginine (GH Pulse) — meta-analysis
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PubMed: L-Arginine (GH Pulse) — pharmacokinetics
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PubMed: L-Arginine (GH Pulse) — safety adverse events
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PubMed: L-Arginine (GH Pulse) — dose response
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Google Scholar: L-Arginine (GH Pulse) — clinical evidence
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