SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

D-Chiro-Inositol

Complementary inositol used in 40:1 myo-inositol ratio for PCOS.

PCOS SupportInsulin SensitivityFemale Fertility

Overview

Complementary inositol used in 40:1 myo-inositol ratio for PCOS.

Natural sources
    Common forms

      Mechanism of action

      Second messenger for insulin in androgen-producing tissues; lowers androgens.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers free T in PCOS women

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Safety & non-supplemental interactions

              Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

              Avoid with these conditions
              • ·Hypoglycemia tendency
              Avoid / monitor with these medications
              • ·Insulin, metformin, sulfonylureas (additive hypoglycemia)

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              50 mg paired with 2 g myo-inositol
              With food?
              Optional

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              D-Chiro-Inos…
              Amazon
              Wide selection · fast shipping
              Compound
              D-Chiro-Inos…
              iHerb
              Global delivery · curated brands
              Compound
              D-Chiro-Inos…
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTN Engl J Med · 1999

              D-chiro-inositol in PCOS

              Nestler JE, et al.

              8-week RCT of DCI 1200 mg in PCOS.

              Key findings

              Improved ovulation, insulin sensitivity, and androgens.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — Lowers free T in PCOS women

              Live PubMed search

              Live results for "D-Chiro-Inositol Lowers free T in PCOS women" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "Lowers free T in PCOS women". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — randomized controlled trial

              Live PubMed search

              Live results for "D-Chiro-Inositol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — meta-analysis

              Live PubMed search

              Live results for "D-Chiro-Inositol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — pharmacokinetics

              Live PubMed search

              Live results for "D-Chiro-Inositol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — safety adverse events

              Live PubMed search

              Live results for "D-Chiro-Inositol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: D-Chiro-Inositol — dose response

              Live PubMed search

              Live results for "D-Chiro-Inositol dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching D-Chiro-Inositol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: D-Chiro-Inositol — clinical evidence

              Live Scholar search

              Cross-database citation index for D-Chiro-Inositol as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.