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evidence · mechanism · dose
Supplements/Compound

Akkermansia muciniphila

Mucin-degrading commensal linked to metabolic health.

Blood Sugar Management

Overview

Mucin-degrading commensal linked to metabolic health.

Natural sources
    Common forms

      Mechanism of action

      Strengthens mucus barrier; modulates GLP-1 and ANGPTL8.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves insulin sensitivity in overweight adults

        Moderate evidence

        Potential side effects

        Common
          Rare
            Serious

              Drug interactions

              No notable interactions reported.

              Supplement interactions

              Pairs well with

              None listed.

              Avoid combining with

              No specific avoidances listed.

              Dosing & bioavailability

              Typical dose
              10 billion pasteurized cells
              With food?
              Either

              Where to buy

              Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

              Compound
              Akkermansia …
              Amazon
              Wide selection · fast shipping
              Compound
              Akkermansia …
              iHerb
              Global delivery · curated brands
              Compound
              Akkermansia …
              Thorne
              Practitioner-grade · NSF tested

              Scientific evidence (8)

              RCTNat Med · 2019

              Pasteurized A. muciniphila in metabolic syndrome

              Depommier C, et al.

              3-month DB-RCT in 32 overweight adults.

              Key findings

              Improved insulin sensitivity and reduced inflammatory markers.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — Improves insulin sensitivity in overweight adults

              Live PubMed search

              Live results for "Akkermansia muciniphila Improves insulin sensitivity in overweight adults" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "Improves insulin sensitivity in overweight adults". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — randomized controlled trial

              Live PubMed search

              Live results for "Akkermansia muciniphila randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — meta-analysis

              Live PubMed search

              Live results for "Akkermansia muciniphila meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — pharmacokinetics

              Live PubMed search

              Live results for "Akkermansia muciniphila pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — safety adverse events

              Live PubMed search

              Live results for "Akkermansia muciniphila safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewPubMed (NLM) · 1970

              PubMed: Akkermansia muciniphila — dose response

              Live PubMed search

              Live results for "Akkermansia muciniphila dose response" across the PubMed/MEDLINE peer-reviewed index.

              Key findings

              Opens current human and preclinical literature matching Akkermansia muciniphila and "dose response". Filter by RCT, meta-analysis, or year on the results page.

              Open study
              Systematic reviewGoogle Scholar · 1970

              Google Scholar: Akkermansia muciniphila — clinical evidence

              Live Scholar search

              Cross-database citation index for Akkermansia muciniphila as it relates to "clinical evidence".

              Key findings

              Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

              Open study
              Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.