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evidence · mechanism · dose
Supplements/Compound

D-Mannose

Simple sugar that binds E. coli fimbriae, flushing them from the urinary tract.

Women's HealthKidney Health

Overview

Simple sugar that binds E. coli fimbriae, flushing them from the urinary tract.

Natural sources
  • Cranberries
  • Apples
  • Peaches
Common forms
  • D-mannose powder

Mechanism of action

E. coli FimH binds mannose preferentially over urothelium, flushing bacteria in urine.

Pathways
  • · Bacterial anti-adhesion

Effects on the body

Decreases
Recurrent UTI episodes

Organ system effects

Kidneys

Comparable to nitrofurantoin for UTI prevention in one RCT.

Evidence-based benefits

Reduces recurrent E. coli UTI

Moderate evidence

Potential side effects

Common
  • · Diarrhea (high dose)
Rare
    Serious

      Drug interactions

      No notable interactions reported.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      2 g × 2–3/d acute; 1–2 g/d prevention

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Compound
      D-Mannose
      Amazon
      Wide selection · fast shipping
      Compound
      D-Mannose
      iHerb
      Global delivery · curated brands
      Compound
      D-Mannose
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      RCTWorld J Urol · 2014

      D-mannose for prevention of recurrent UTI

      Kranjčec B, et al.

      RCT of D-mannose vs nitrofurantoin vs no prophylaxis.

      Key findings

      Comparable to antibiotics with fewer side effects.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — Reduces recurrent E. coli UTI

      Live PubMed search

      Live results for "D-Mannose Reduces recurrent E. coli UTI" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "Reduces recurrent E. coli UTI". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — randomized controlled trial

      Live PubMed search

      Live results for "D-Mannose randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — meta-analysis

      Live PubMed search

      Live results for "D-Mannose meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — pharmacokinetics

      Live PubMed search

      Live results for "D-Mannose pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — safety adverse events

      Live PubMed search

      Live results for "D-Mannose safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: D-Mannose — dose response

      Live PubMed search

      Live results for "D-Mannose dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching D-Mannose and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: D-Mannose — clinical evidence

      Live Scholar search

      Cross-database citation index for D-Mannose as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.