SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Ashwagandha (Strength)

KSM-66 dose for resistance training adaptations.

Muscle GrowthAthletic PerformanceTestosterone Support

Overview

KSM-66 dose for resistance training adaptations.

Natural sources
    Common forms

      Forms & variants of Ashwagandha

      Different chemical forms of Ashwagandha behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Ashwagandha

      Adaptogenic herb that down-regulates HPA-axis output — lowers cortisol, supports T in stressed men.

      KSM-66 (root extract)
      KSM-66 Ashwagandha

      Root-only standardized ashwagandha extract — the most-studied form for stress and T-support.

      Sensoril (root + leaf)
      Sensoril Ashwagandha

      Root + leaf extract standardized to ≥10% withanolides — higher potency, more sedating.

      Mechanism of action

      Reduces cortisol and supports anabolic environment.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases muscle strength and size with training

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
            Avoid / monitor with these medications
            • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            600 mg KSM-66
            With food?
            With meals

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Ashwagandha …
            Amazon
            Wide selection · fast shipping
            Herb
            Ashwagandha …
            iHerb
            Global delivery · curated brands
            Herb
            Ashwagandha …
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Int Soc Sports Nutr · 2015

            Ashwagandha and resistance training

            Wankhede S, et al.

            8-week DB-RCT in 57 young men.

            Key findings

            Greater strength, hypertrophy, and testosterone vs placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — Increases muscle strength and size with training

            Live PubMed search

            Live results for "Ashwagandha (Strength) Increases muscle strength and size with training" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "Increases muscle strength and size with training". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — randomized controlled trial

            Live PubMed search

            Live results for "Ashwagandha (Strength) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — meta-analysis

            Live PubMed search

            Live results for "Ashwagandha (Strength) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — pharmacokinetics

            Live PubMed search

            Live results for "Ashwagandha (Strength) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — safety adverse events

            Live PubMed search

            Live results for "Ashwagandha (Strength) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Ashwagandha (Strength) — dose response

            Live PubMed search

            Live results for "Ashwagandha (Strength) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Ashwagandha (Strength) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Ashwagandha (Strength) — clinical evidence

            Live Scholar search

            Cross-database citation index for Ashwagandha (Strength) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.