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Supplements/Vitamin

Biotin (Hair Dose)

B-vitamin used cosmetically for hair and nail growth.

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Overview

B-vitamin used cosmetically for hair and nail growth.

Natural sources
  • Whole-food sources (animal products for fat-soluble and B-complex vitamins; produce for water-soluble vitamins)
  • Fortified foods (cereals, dairy, plant milks, nutritional yeast)
  • Multivitamins or stand-alone supplements in synthetic or food-derived form
Common forms
  • Capsule or softgel
  • Sublingual tablet or liquid
  • Methylated active form for sensitive individuals
  • Multivitamin matrix

Forms & variants of Biotin (B7)

Different chemical forms of Biotin (B7) behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Mechanism of action

Cofactor for carboxylase enzymes; influences keratin gene expression.

Pathways
  • · Cofactor for carboxylase enzymes
  • · influences keratin gene expression

Effects on the body

Supports
brittle nails
Supports
Hair benefits only in deficiency

Organ system effects

Skin

Biotin (Hair Dose) supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.

Evidence-based benefits

Improves brittle nails

Moderate evidence

Hair benefits only in deficiency

Limited evidence

Potential side effects

Common
    Rare
    • · Acne with very high dose
    Serious
    • · Interferes with thyroid, troponin labs

    Drug interactions

    Prescription medications (general)
    Always disclose Biotin (Hair Dose) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
    minor

    Supplement interactions

    Pairs well with
    • Collagen peptides
      Provides amino acid substrate for connective tissue synthesis.
    • Vitamin C
      Required cofactor for collagen hydroxylation.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    2500–5000 mcg
    Best form
    Most evidence is based on the capsule or softgel form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Either

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence9Show studies
    CohortCutis · 1993

    Biotin for brittle nails

    Hochman LG, et al.

    Open trial in 35 patients with brittle nails.

    Key findings

    2.5 mg/day biotin increased nail thickness by 25% on average.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — Improves brittle nails

    Live PubMed search

    Live results for "Biotin (Hair Dose) Improves brittle nails" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "Improves brittle nails". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — Hair benefits only in deficiency

    Live PubMed search

    Live results for "Biotin (Hair Dose) Hair benefits only in deficiency" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "Hair benefits only in deficiency". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — randomized controlled trial

    Live PubMed search

    Live results for "Biotin (Hair Dose) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — meta-analysis

    Live PubMed search

    Live results for "Biotin (Hair Dose) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — pharmacokinetics

    Live PubMed search

    Live results for "Biotin (Hair Dose) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — safety adverse events

    Live PubMed search

    Live results for "Biotin (Hair Dose) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Biotin (Hair Dose) — dose response

    Live PubMed search

    Live results for "Biotin (Hair Dose) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Biotin (Hair Dose) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Biotin (Hair Dose) — clinical evidence

    Live Scholar search

    Cross-database citation index for Biotin (Hair Dose) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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