Overview
GLA omega-6 for skin and PMS.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
GLA converted to anti-inflammatory prostaglandins.
- · GLA converted to anti-inflammatory prostaglandins
Effects on the body
Organ system effects
Evening Primrose Oil has documented effects on female reproductive endocrinology and cycle regulation.
Evening Primrose Oil supports collagen synthesis, antioxidant defense, or barrier function in skin and integumentary tissues.
Evidence-based benefits
Mixed for PMS
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Evening Primrose Oil — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Evening Primrose Oil third party tested NSF
CapsulesPre-measured Evening Primrose Oil capsules — easiest for travel and consistent daily dosing without scoops or scales.Evening Primrose Oil capsules
PowderBulk unflavored Evening Primrose Oil powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Evening Primrose Oil powder unflavored
Best sellersMost-purchased Evening Primrose Oil products on Amazon — a quick way to see what's reviewed widely before you commit.Evening Primrose Oil best sellerScientific evidence8Show studiesHide studies
EPO for PMS
Khoo SK, et al.
7 trials
No clear benefit over placebo.
PubMed: Evening Primrose Oil — Mixed for PMS
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PubMed: Evening Primrose Oil — randomized controlled trial
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PubMed: Evening Primrose Oil — meta-analysis
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PubMed: Evening Primrose Oil — pharmacokinetics
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PubMed: Evening Primrose Oil — safety adverse events
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PubMed: Evening Primrose Oil — dose response
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Google Scholar: Evening Primrose Oil — clinical evidence
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Cross-database citation index for Evening Primrose Oil as it relates to "clinical evidence".
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