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evidence · mechanism · dose
Supplements/Fatty Acid

Evening Primrose Oil

GLA omega-6 for skin and PMS.

Women's HealthSkin, Hair & Nails

Overview

GLA omega-6 for skin and PMS.

Natural sources
    Common forms

      Mechanism of action

      GLA converted to anti-inflammatory prostaglandins.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Mixed for PMS

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1300 mg GLA

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            Meta-analysisMed J Aust · 1990

            EPO for PMS

            Khoo SK, et al.

            7 trials

            Key findings

            No clear benefit over placebo.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — Mixed for PMS

            Live PubMed search

            Live results for "Evening Primrose Oil Mixed for PMS" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "Mixed for PMS". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — randomized controlled trial

            Live PubMed search

            Live results for "Evening Primrose Oil randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — meta-analysis

            Live PubMed search

            Live results for "Evening Primrose Oil meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — pharmacokinetics

            Live PubMed search

            Live results for "Evening Primrose Oil pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — safety adverse events

            Live PubMed search

            Live results for "Evening Primrose Oil safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Evening Primrose Oil — dose response

            Live PubMed search

            Live results for "Evening Primrose Oil dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Evening Primrose Oil and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Evening Primrose Oil — clinical evidence

            Live Scholar search

            Cross-database citation index for Evening Primrose Oil as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.