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evidence · mechanism · dose
Supplements/Herb

Olive Leaf Extract

aka Oleuropein

Polyphenol-rich leaf extract for blood pressure and glucose.

Blood Sugar Management

Overview

Polyphenol-rich leaf extract for blood pressure and glucose.

Natural sources
    Common forms

      Mechanism of action

      Oleuropein increases NO, inhibits ACE, and improves insulin sensitivity.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Lowers SBP/DBP in mild hypertension

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            Antihypertensives
            Additive hypotension.
            moderate

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            500–1000 mg standardized
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Olive Leaf E…
            Amazon
            Wide selection · fast shipping
            Herb
            Olive Leaf E…
            iHerb
            Global delivery · curated brands
            Herb
            Olive Leaf E…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTPhytomedicine · 2011

            Olive leaf vs captopril in HTN

            Susalit E, et al.

            8-week DB-RCT in 232 stage-1 HTN patients.

            Key findings

            Olive leaf 500 mg bid equivalent to captopril 12.5–25 mg bid.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — Lowers SBP/DBP in mild hypertension

            Live PubMed search

            Live results for "Olive Leaf Extract Lowers SBP/DBP in mild hypertension" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "Lowers SBP/DBP in mild hypertension". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — randomized controlled trial

            Live PubMed search

            Live results for "Olive Leaf Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — meta-analysis

            Live PubMed search

            Live results for "Olive Leaf Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — pharmacokinetics

            Live PubMed search

            Live results for "Olive Leaf Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — safety adverse events

            Live PubMed search

            Live results for "Olive Leaf Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Olive Leaf Extract — dose response

            Live PubMed search

            Live results for "Olive Leaf Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Olive Leaf Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Olive Leaf Extract — clinical evidence

            Live Scholar search

            Cross-database citation index for Olive Leaf Extract as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.