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Olive Leaf Extract

aka Oleuropein

Polyphenol-rich leaf extract for blood pressure and glucose.

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Overview

Polyphenol-rich leaf extract for blood pressure and glucose.

Natural sources
  • Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
  • Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
  • Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
Common forms
  • Standardized extract capsule
  • Liquid tincture (alcohol or glycerin)
  • Powdered whole herb
  • Traditional decoction or tea

Mechanism of action

Oleuropein increases NO, inhibits ACE, and improves insulin sensitivity.

Pathways
  • · Oleuropein increases NO, inhibits ACE
  • · and improves insulin sensitivity

Effects on the body

Decreases
SBP/DBP in mild hypertension

Organ system effects

Evidence-based benefits

Lowers SBP/DBP in mild hypertension

Moderate evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious

      Drug interactions

      Antihypertensives
      Additive hypotension.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      500–1000 mg standardized
      Best form
      Most evidence is based on the standardized extract capsule form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With food

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTPhytomedicine · 2011

      Olive leaf vs captopril in HTN

      Susalit E, et al.

      8-week DB-RCT in 232 stage-1 HTN patients.

      Key findings

      Olive leaf 500 mg bid equivalent to captopril 12.5–25 mg bid.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — Lowers SBP/DBP in mild hypertension

      Live PubMed search

      Live results for "Olive Leaf Extract Lowers SBP/DBP in mild hypertension" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "Lowers SBP/DBP in mild hypertension". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — randomized controlled trial

      Live PubMed search

      Live results for "Olive Leaf Extract randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — meta-analysis

      Live PubMed search

      Live results for "Olive Leaf Extract meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — pharmacokinetics

      Live PubMed search

      Live results for "Olive Leaf Extract pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — safety adverse events

      Live PubMed search

      Live results for "Olive Leaf Extract safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Olive Leaf Extract — dose response

      Live PubMed search

      Live results for "Olive Leaf Extract dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Olive Leaf Extract and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Olive Leaf Extract — clinical evidence

      Live Scholar search

      Cross-database citation index for Olive Leaf Extract as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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