Overview
Soy isoflavone with bone benefits.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
ERβ agonist; tyrosine kinase inhibitor.
- · ERβ agonist
- · tyrosine kinase inhibitor
Effects on the body
Organ system effects
Genistein contributes to bone mineralization, osteoblast activity, or calcium-phosphate homeostasis.
Genistein has documented effects on female reproductive endocrinology and cycle regulation.
Evidence-based benefits
Reduces bone loss
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Genistein — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Genistein third party tested NSF
CapsulesPre-measured Genistein capsules — easiest for travel and consistent daily dosing without scoops or scales.Genistein capsules
PowderBulk unflavored Genistein powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Genistein powder unflavored
Best sellersMost-purchased Genistein products on Amazon — a quick way to see what's reviewed widely before you commit.Genistein best sellerScientific evidence8Show studiesHide studies
Genistein for bone
Marini H, et al.
389 women
Increased BMD vs placebo over 2 years.
PubMed: Genistein — Reduces bone loss
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Live results for "Genistein Reduces bone loss" across the PubMed/MEDLINE peer-reviewed index.
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PubMed: Genistein — randomized controlled trial
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PubMed: Genistein — meta-analysis
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PubMed: Genistein — pharmacokinetics
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PubMed: Genistein — safety adverse events
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PubMed: Genistein — dose response
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Google Scholar: Genistein — clinical evidence
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Cross-database citation index for Genistein as it relates to "clinical evidence".
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