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evidence · mechanism · dose
Supplements/Herb

Fadogia Agrestis

African shrub touted for testosterone (rodent data only).

Testosterone SupportLibido & Sexual HealthMen's Health

Overview

African shrub touted for testosterone (rodent data only).

Natural sources
    Common forms

      Forms & variants of Fadogia Agrestis

      Different chemical forms of Fadogia Agrestis behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Fadogia Agrestis

      African shrub popularized for testosterone; limited human data and toxicology concerns.

      Parent
      Fadogia Agrestis

      Nigerian shrub — popularized for testosterone support; sparse human data.

      Mechanism of action

      Putative gonadotropin-mimetic in rats; mechanism in humans unclear.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Increases testosterone in rats

        Limited evidence

        Potential side effects

        Common
          Rare
            Serious
            • · Possible testicular toxicity at high doses

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Avoid with these conditions
            • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
            Avoid / monitor with these medications
            • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            300–600 mg (experimental)

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Herb
            Fadogia Agre…
            Amazon
            Wide selection · fast shipping
            Herb
            Fadogia Agre…
            iHerb
            Global delivery · curated brands
            Herb
            Fadogia Agre…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            AnimalAsian J Androl · 2005

            Fadogia in male rats

            Yakubu MT, et al.

            Rats given Fadogia extract for 5 days.

            Key findings

            Increased serum testosterone; mild testicular changes at high dose.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — Increases testosterone in rats

            Live PubMed search

            Live results for "Fadogia Agrestis Increases testosterone in rats" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fadogia Agrestis and "Increases testosterone in rats". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — randomized controlled trial

            Live PubMed search

            Live results for "Fadogia Agrestis randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fadogia Agrestis and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — meta-analysis

            Live PubMed search

            Live results for "Fadogia Agrestis meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Fadogia Agrestis and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — pharmacokinetics

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            Live results for "Fadogia Agrestis pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — safety adverse events

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            Live results for "Fadogia Agrestis safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Fadogia Agrestis — dose response

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            Live results for "Fadogia Agrestis dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

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            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Fadogia Agrestis — clinical evidence

            Live Scholar search

            Cross-database citation index for Fadogia Agrestis as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.