SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Herb

Fadogia Agrestis

African shrub popularized for testosterone; limited human data and toxicology concerns.

Testosterone SupportMen's Health

Overview

African shrub popularized for testosterone; limited human data and toxicology concerns.

Natural sources
  • Fadogia agrestis stem
Common forms
  • Standardized extract

Forms & variants of Fadogia Agrestis

Different chemical forms of Fadogia Agrestis behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Extract dose
Fadogia Agrestis

African shrub touted for testosterone (rodent data only).

Mechanism of action

Animal studies suggest steroidogenic effects on Leydig cells; no human trials.

Pathways
  • · Leydig cell stimulation (animal)

Effects on the body

Increases
Testosterone (rodent)

Organ system effects

Reproductive

Rodent studies show LH/T increase; testicular toxicity at high doses.

Evidence-based benefits

No human RCTs

Anecdotal

Potential side effects

Common
    Rare
      Serious
      • · Possible testicular/hepatic toxicity (rodent at high dose)

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Avoid with these conditions
      • ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
      Avoid / monitor with these medications
      • ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with
      • Pregnancy
        No safety data.

      Dosing & bioavailability

      Typical dose
      300–600 mg (anecdotal); no validated human dosing

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Fadogia Agre…
      Amazon
      Wide selection · fast shipping
      Herb
      Fadogia Agre…
      iHerb
      Global delivery · curated brands
      Herb
      Fadogia Agre…
      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      AnimalAsian J Androl · 2005

      Aphrodisiac potential of Fadogia agrestis stem in male rats

      Yakubu MT, et al.

      Rodent study of Fadogia aqueous extract on libido and serum testosterone.

      Key findings

      Dose-dependent increases in mount frequency and serum testosterone; no human RCTs yet.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — No human RCTs

      Live PubMed search

      Live results for "Fadogia Agrestis No human RCTs" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "No human RCTs". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — randomized controlled trial

      Live PubMed search

      Live results for "Fadogia Agrestis randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — meta-analysis

      Live PubMed search

      Live results for "Fadogia Agrestis meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — pharmacokinetics

      Live PubMed search

      Live results for "Fadogia Agrestis pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — safety adverse events

      Live PubMed search

      Live results for "Fadogia Agrestis safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Fadogia Agrestis — dose response

      Live PubMed search

      Live results for "Fadogia Agrestis dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Fadogia Agrestis and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Fadogia Agrestis — clinical evidence

      Live Scholar search

      Cross-database citation index for Fadogia Agrestis as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.