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evidence · mechanism · dose
Supplements/Peptide

Biotinyl Tripeptide-1 (Procapil)

Topical peptide complex marketed for hair anchoring.

Skin, Hair & Nails

Overview

Topical peptide complex marketed for hair anchoring.

Natural sources
    Common forms

      Mechanism of action

      Stimulates anagen markers and follicle anchoring proteins (laminin, integrin).

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Improves hair density in pilot trials

        Limited evidence

        Potential side effects

        Common
        • · Scalp irritation
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Safety & non-supplemental interactions

            Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

            Avoid if you are
            • ·Pregnant or breastfeeding (insufficient safety data)
            • ·Children under 18 (unless directed by a clinician)
            Other notes
            • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            3% topical, daily

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Peptide
            Biotinyl Tri…
            Amazon
            Wide selection · fast shipping
            Peptide
            Biotinyl Tri…
            iHerb
            Global delivery · curated brands
            Peptide
            Biotinyl Tri…
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortManufacturer monograph · 2003

            Procapil for androgenetic alopecia

            Sederma Inc.

            Open-label trial in 30 men.

            Key findings

            Increased hair density and reduced shedding after 4 months.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — Improves hair density in pilot trials

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) Improves hair density in pilot trials" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "Improves hair density in pilot trials". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — randomized controlled trial

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — meta-analysis

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — pharmacokinetics

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — safety adverse events

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Biotinyl Tripeptide-1 (Procapil) — dose response

            Live PubMed search

            Live results for "Biotinyl Tripeptide-1 (Procapil) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Biotinyl Tripeptide-1 (Procapil) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Biotinyl Tripeptide-1 (Procapil) — clinical evidence

            Live Scholar search

            Cross-database citation index for Biotinyl Tripeptide-1 (Procapil) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.