Overview
Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Blocks alpha-2 adrenergic auto-receptors, releasing norepinephrine; counters anti-erectile sympathetic tone.
- · Alpha-2 antagonism
- · Lipolysis
Effects on the body
Organ system effects
Yohimbine influences androgen signaling, prostate health, or male reproductive function.
Evidence-based benefits
Effective for psychogenic ED
Moderate evidenceIncreases fasted lipolysis
Moderate evidencePotential side effects
- · Anxiety
- · Tachycardia
- · HTN
- · Hypertensive crisis
- · Panic attacks
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding
- ·Anxiety / panic disorder, PTSD, schizophrenia
- ·Hypertension or cardiovascular disease
- ·Kidney or liver disease
- ·Prostate disorders
- ·MAOIs, SSRIs, TCAs
- ·Stimulants, caffeine (additive cardiovascular)
- ·Antihypertensives (unpredictable BP)
- ·Naloxone, opioids
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Yohimbine — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Yohimbine third party tested NSF
CapsulesPre-measured Yohimbine capsules — easiest for travel and consistent daily dosing without scoops or scales.Yohimbine capsules
PowderBulk unflavored Yohimbine powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Yohimbine powder unflavored
Best sellersMost-purchased Yohimbine products on Amazon — a quick way to see what's reviewed widely before you commit.Yohimbine best sellerScientific evidence9Show studiesHide studies
Yohimbine for erectile dysfunction: a meta-analysis
Ernst E, Pittler MH
Meta-analysis of yohimbine RCTs.
More effective than placebo for erectile dysfunction.
PubMed: Yohimbine — Effective for psychogenic ED
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PubMed: Yohimbine — Increases fasted lipolysis
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PubMed: Yohimbine — randomized controlled trial
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PubMed: Yohimbine — meta-analysis
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PubMed: Yohimbine — pharmacokinetics
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PubMed: Yohimbine — safety adverse events
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PubMed: Yohimbine — dose response
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Google Scholar: Yohimbine — clinical evidence
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Cross-database citation index for Yohimbine as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.