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evidence · mechanism · dose
Supplements/Compound

Yohimbine

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Erectile FunctionFat Loss (alias)Libido & Sexual HealthMen's Health

Overview

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Natural sources
    Common forms

      Mechanism of action

      Blocks alpha-2 adrenergic auto-receptors, releasing norepinephrine; counters anti-erectile sympathetic tone.

      Pathways
      • · Alpha-2 antagonism
      • · Lipolysis

      Effects on the body

      Increases
      Norepinephrine release
      Supports
      Erectile response

      Organ system effects

      Evidence-based benefits

      Effective for psychogenic ED

      Moderate evidence

      Increases fasted lipolysis

      Moderate evidence

      Potential side effects

      Common
      • · Anxiety
      • · Tachycardia
      • · HTN
      Rare
        Serious
        • · Hypertensive crisis
        • · Panic attacks

        Drug interactions

        MAOIs/SSRIs
        Serotonergic and adrenergic risk.
        severe
        Anti-hypertensives
        Interferes with control.
        moderate

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding
        Avoid with these conditions
        • ·Anxiety / panic disorder, PTSD, schizophrenia
        • ·Hypertension or cardiovascular disease
        • ·Kidney or liver disease
        • ·Prostate disorders
        Avoid / monitor with these medications
        • ·MAOIs, SSRIs, TCAs
        • ·Stimulants, caffeine (additive cardiovascular)
        • ·Antihypertensives (unpredictable BP)
        • ·Naloxone, opioids

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        0.2 mg/kg fasted (≈10–15 mg)
        Upper safe limit
        Avoid in HTN/anxiety
        With food?
        Empty stomach

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Yohimbine
        Amazon
        Wide selection · fast shipping
        Compound
        Yohimbine
        iHerb
        Global delivery · curated brands
        Compound
        Yohimbine
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        Meta-analysisJ Urol · 1998

        Yohimbine for erectile dysfunction: a meta-analysis

        Ernst E, Pittler MH

        Meta-analysis of yohimbine RCTs.

        Key findings

        More effective than placebo for erectile dysfunction.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — Effective for psychogenic ED

        Live PubMed search

        Live results for "Yohimbine Effective for psychogenic ED" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "Effective for psychogenic ED". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — Increases fasted lipolysis

        Live PubMed search

        Live results for "Yohimbine Increases fasted lipolysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "Increases fasted lipolysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — randomized controlled trial

        Live PubMed search

        Live results for "Yohimbine randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — meta-analysis

        Live PubMed search

        Live results for "Yohimbine meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — pharmacokinetics

        Live PubMed search

        Live results for "Yohimbine pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — safety adverse events

        Live PubMed search

        Live results for "Yohimbine safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Yohimbine — dose response

        Live PubMed search

        Live results for "Yohimbine dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Yohimbine and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Yohimbine — clinical evidence

        Live Scholar search

        Cross-database citation index for Yohimbine as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.