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evidence · mechanism · dose
Supplements/Amino Acid

Glycine (Collagen Stack)

Free-form glycine paired with collagen for connective tissue synthesis.

Skin, Hair & Nails

Overview

Free-form glycine paired with collagen for connective tissue synthesis.

Natural sources
    Common forms

      Forms & variants of Glycine

      Different chemical forms of Glycine behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Glycine

      Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.

      Parent
      Glycine

      Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.

      Mechanism of action

      Glycine is rate-limiting for collagen triple helix formation.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Supports collagen synthesis when paired with vitamin C

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            5–10 g with collagen
            With food?
            Either

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            CohortJ Biosci · 2009

            Glycine intake and collagen turnover

            Meléndez-Hevia E, et al.

            Metabolic balance analysis.

            Key findings

            Endogenous glycine production insufficient for collagen needs.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — Supports collagen synthesis when paired with vitamin C

            Live PubMed search

            Live results for "Glycine (Collagen Stack) Supports collagen synthesis when paired with vitamin C" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "Supports collagen synthesis when paired with vitamin C". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — randomized controlled trial

            Live PubMed search

            Live results for "Glycine (Collagen Stack) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — meta-analysis

            Live PubMed search

            Live results for "Glycine (Collagen Stack) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — pharmacokinetics

            Live PubMed search

            Live results for "Glycine (Collagen Stack) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — safety adverse events

            Live PubMed search

            Live results for "Glycine (Collagen Stack) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Glycine (Collagen Stack) — dose response

            Live PubMed search

            Live results for "Glycine (Collagen Stack) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Glycine (Collagen Stack) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Glycine (Collagen Stack) — clinical evidence

            Live Scholar search

            Cross-database citation index for Glycine (Collagen Stack) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.