Overview
Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
- Oenothera biennis seeds
- EPO standardized to GLA
Mechanism of action
GLA converts to DGLA, producing anti-inflammatory PGE1.
- · PGE1 synthesis
Effects on the body
Organ system effects
Mixed evidence in atopic dermatitis.
Evidence-based benefits
Modest improvement in cyclical breast pain
Limited evidenceMixed for atopic dermatitis
Limited evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- Collagen peptidesProvides amino acid substrate for connective tissue synthesis.
- Vitamin CRequired cofactor for collagen hydroxylation.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Evening Primrose Oil — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Evening Primrose Oil third party tested NSF
CapsulesPre-measured Evening Primrose Oil capsules — easiest for travel and consistent daily dosing without scoops or scales.Evening Primrose Oil capsules
PowderBulk unflavored Evening Primrose Oil powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Evening Primrose Oil powder unflavored
Best sellersMost-purchased Evening Primrose Oil products on Amazon — a quick way to see what's reviewed widely before you commit.Evening Primrose Oil best sellerScientific evidence9Show studiesHide studies
Evening primrose oil for mastalgia and PMS
Pruthi S, et al.
Review of EPO trials in breast pain and PMS.
Limited efficacy beyond placebo; safe profile.
PubMed: Evening Primrose Oil — Modest improvement in cyclical breast pain
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