Overview
Active flavonoid from Epimedium acting as PDE5 inhibitor.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Selective PDE5 inhibition increases cGMP in cavernosal tissue; mild estrogenic activity on bone.
- · Selective PDE5 inhibition increases cGMP in cavernosal tissue
- · mild estrogenic activity on bone
Effects on the body
Organ system effects
Icariin (Horny Goat Weed) contributes to bone mineralization, osteoblast activity, or calcium-phosphate homeostasis.
Evidence-based benefits
Improves erectile function in animal models
Moderate evidencePotential side effects
- · GI upset
- · Tachycardia
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Hormone-sensitive cancers (breast, prostate, ovarian, uterine)
- ·Hormonal contraceptives, HRT, tamoxifen, aromatase inhibitors
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Icariin (Horny Goat Weed) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Icariin (Horny Goat Weed) third party tested NSF
CapsulesPre-measured Icariin (Horny Goat Weed) capsules — easiest for travel and consistent daily dosing without scoops or scales.Icariin (Horny Goat Weed) capsules
PowderBulk unflavored Icariin (Horny Goat Weed) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Icariin (Horny Goat Weed) powder unflavored
Best sellersMost-purchased Icariin (Horny Goat Weed) products on Amazon — a quick way to see what's reviewed widely before you commit.Icariin (Horny Goat Weed) best sellerScientific evidence8Show studiesHide studies
Icariin restores erectile function in diabetic rats
Liu T, et al.
STZ-diabetic rat ED model.
Icariin improved ICP/MAP ratio comparable to sildenafil.
PubMed: Icariin (Horny Goat Weed) — Improves erectile function in animal models
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Google Scholar: Icariin (Horny Goat Weed) — clinical evidence
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