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Supplements/Compound

Glucomannan (Konjac)

Viscous soluble fiber that promotes satiety and lowers LDL.

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Overview

Viscous soluble fiber that promotes satiety and lowers LDL.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Expands in stomach to slow gastric emptying; binds bile acids.

Pathways
  • · Expands in stomach to slow gastric emptying
  • · binds bile acids

Effects on the body

Supports
Modest weight loss as part of hypocaloric diet
Decreases
LDL ~10%

Organ system effects

Evidence-based benefits

Modest weight loss as part of hypocaloric diet

Moderate evidence

Lowers LDL ~10%

Strong evidence

Potential side effects

Common
  • · Bloating
  • · Choking risk if dry
Rare
    Serious
    • · Esophageal obstruction if not taken with water

    Drug interactions

    Oral medications
    Take 1 h apart due to absorption interference.
    moderate

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    1 g tid with 250 mL water
    Best form
    Most evidence is based on the capsule or softgel form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Before meals

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence9Show studies
    RCTPhytother Res · 2008

    Glucomannan in overweight adults

    Vasques CA, et al.

    16-week DB-RCT in 58 overweight adults.

    Key findings

    Modest weight reduction and improved lipid profile.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — Modest weight loss as part of hypocaloric diet

    Live PubMed search

    Live results for "Glucomannan (Konjac) Modest weight loss as part of hypocaloric diet" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "Modest weight loss as part of hypocaloric diet". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — Lowers LDL ~10%

    Live PubMed search

    Live results for "Glucomannan (Konjac) Lowers LDL ~10%" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "Lowers LDL ~10%". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — randomized controlled trial

    Live PubMed search

    Live results for "Glucomannan (Konjac) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — meta-analysis

    Live PubMed search

    Live results for "Glucomannan (Konjac) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — pharmacokinetics

    Live PubMed search

    Live results for "Glucomannan (Konjac) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — safety adverse events

    Live PubMed search

    Live results for "Glucomannan (Konjac) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Glucomannan (Konjac) — dose response

    Live PubMed search

    Live results for "Glucomannan (Konjac) dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Glucomannan (Konjac) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Glucomannan (Konjac) — clinical evidence

    Live Scholar search

    Cross-database citation index for Glucomannan (Konjac) as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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