Overview
Diabetes drug studied for longevity (TAME trial) via AMPK activation.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Inhibits mitochondrial complex I → AMPK activation; reduces hepatic gluconeogenesis.
- · Inhibits mitochondrial complex I → AMPK activation
- · reduces hepatic gluconeogenesis
Effects on the body
Organ system effects
Evidence-based benefits
Lowers all-cause mortality in T2D
Strong evidenceLongevity benefit in non-diabetics unproven (TAME)
Limited evidencePotential side effects
- · GI upset
- · B12 depletion
- · Lactic acidosis (renal)
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Hypoglycemia tendency
- ·Insulin, metformin, sulfonylureas (additive hypoglycemia)
Supplement interactions
- Vitamin B12Long-term metformin depletes B12.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Metformin (Rx, reference) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Metformin (Rx, reference) third party tested NSF
CapsulesPre-measured Metformin (Rx, reference) capsules — easiest for travel and consistent daily dosing without scoops or scales.Metformin (Rx, reference) capsules
PowderBulk unflavored Metformin (Rx, reference) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Metformin (Rx, reference) powder unflavored
Best sellersMost-purchased Metformin (Rx, reference) products on Amazon — a quick way to see what's reviewed widely before you commit.Metformin (Rx, reference) best sellerScientific evidence9Show studiesHide studies
Metformin and aging: the TAME trial rationale
Barzilai N, et al.
Review of metformin's geroprotective evidence.
Associated with reduced age-related disease in observational data.
PubMed: Metformin (Rx, reference) — Lowers all-cause mortality in T2D
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PubMed: Metformin (Rx, reference) — Longevity benefit in non-diabetics unproven
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PubMed: Metformin (Rx, reference) — randomized controlled trial
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PubMed: Metformin (Rx, reference) — meta-analysis
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PubMed: Metformin (Rx, reference) — dose response
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Google Scholar: Metformin (Rx, reference) — clinical evidence
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