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evidence · mechanism · dose
Supplements/Herb

Red Clover

aka Trifolium pratense

Isoflavone-rich legume traditionally used for menopausal symptoms.

Women's Health

Overview

Isoflavone-rich legume traditionally used for menopausal symptoms.

Natural sources
  • Trifolium pratense
Common forms
  • Standardized isoflavones (Promensil)

Mechanism of action

Isoflavones (biochanin A, formononetin) act as SERMs.

Pathways
  • · ER modulation
Hormones
  • · Estrogen receptors

Effects on the body

Supports
Bone density (modest)

Organ system effects

Reproductive

Mixed evidence for hot flashes.

Evidence-based benefits

Mixed evidence for hot flash reduction

Limited evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        Anticoagulants
        Coumarins.
        moderate
        Hormone therapy
        Additive.
        moderate

        Safety & non-supplemental interactions

        Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

        Avoid if you are
        • ·Pregnant or breastfeeding (insufficient safety data)
        • ·Children under 18 (unless directed by a clinician)

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with
        • Hormone-sensitive cancers
          Phytoestrogenic.

        Dosing & bioavailability

        Typical dose
        40–80 mg isoflavones

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Herb
        Red Clover
        Amazon
        Wide selection · fast shipping
        Herb
        Red Clover
        iHerb
        Global delivery · curated brands
        Herb
        Red Clover
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (8)

        Meta-analysisCochrane Database · 2013

        Red clover isoflavones for menopausal symptoms

        Lethaby A, et al.

        Cochrane review of phytoestrogens in menopause.

        Key findings

        Small reduction in hot flashes vs placebo.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — Mixed evidence for hot flash reduction

        Live PubMed search

        Live results for "Red Clover Mixed evidence for hot flash reduction" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "Mixed evidence for hot flash reduction". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — randomized controlled trial

        Live PubMed search

        Live results for "Red Clover randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — meta-analysis

        Live PubMed search

        Live results for "Red Clover meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — pharmacokinetics

        Live PubMed search

        Live results for "Red Clover pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — safety adverse events

        Live PubMed search

        Live results for "Red Clover safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Red Clover — dose response

        Live PubMed search

        Live results for "Red Clover dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Red Clover and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Red Clover — clinical evidence

        Live Scholar search

        Cross-database citation index for Red Clover as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.