Overview
Urtica dioica for BPH.
- Whole dried plant material (root, leaf, flower, or aerial parts depending on the species)
- Standardized hydroethanolic or aqueous extract (capsule, tincture, or tea)
- Powdered traditional preparation used in Ayurvedic, TCM, or Western herbal practice
- Standardized extract capsule
- Liquid tincture (alcohol or glycerin)
- Powdered whole herb
- Traditional decoction or tea
Mechanism of action
Binds SHBG; weak 5-AR inhibition.
- · Binds SHBG
- · weak 5-AR inhibition
Effects on the body
Organ system effects
Nettle Root influences androgen signaling, prostate health, or male reproductive function.
Evidence-based benefits
Mild BPH improvement
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Safety & non-supplemental interactions
Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.
- ·Pregnant or breastfeeding (insufficient safety data)
- ·Children under 18 (unless directed by a clinician)
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified Nettle Root — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Nettle Root third party tested NSF
CapsulesPre-measured Nettle Root capsules — easiest for travel and consistent daily dosing without scoops or scales.Nettle Root capsules
PowderBulk unflavored Nettle Root powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Nettle Root powder unflavored
Best sellersMost-purchased Nettle Root products on Amazon — a quick way to see what's reviewed widely before you commit.Nettle Root best sellerScientific evidence8Show studiesHide studies
Nettle root in BPH
Safarinejad MR
620 patients
Improved IPSS score vs placebo.
PubMed: Nettle Root — Mild BPH improvement
Live PubMed search
Live results for "Nettle Root Mild BPH improvement" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "Mild BPH improvement". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Nettle Root — randomized controlled trial
Live PubMed search
Live results for "Nettle Root randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Nettle Root — meta-analysis
Live PubMed search
Live results for "Nettle Root meta-analysis" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Nettle Root — pharmacokinetics
Live PubMed search
Live results for "Nettle Root pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Nettle Root — safety adverse events
Live PubMed search
Live results for "Nettle Root safety adverse events" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.
PubMed: Nettle Root — dose response
Live PubMed search
Live results for "Nettle Root dose response" across the PubMed/MEDLINE peer-reviewed index.
Opens current human and preclinical literature matching Nettle Root and "dose response". Filter by RCT, meta-analysis, or year on the results page.
Google Scholar: Nettle Root — clinical evidence
Live Scholar search
Cross-database citation index for Nettle Root as it relates to "clinical evidence".
Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.