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evidence · mechanism · dose
Supplements/Peptide

GHK-Cu (Copper Peptide)

Copper-binding tripeptide used topically for skin remodeling.

Skin, Hair & Nails

Overview

Copper-binding tripeptide used topically for skin remodeling.

Natural sources
  • Synthetic
Common forms
  • Topical serum
  • Injectable (off-label)

Mechanism of action

Copper carrier that activates fibroblast proliferation and collagen synthesis.

Pathways
  • · Collagen synthesis ↑

Effects on the body

Supports
Skin remodeling

Organ system effects

Skin

Improves fine lines and wound healing.

Evidence-based benefits

Topical improves skin elasticity and wound healing

Moderate evidence

Potential side effects

Common
  • · Skin irritation
Rare
    Serious

      Drug interactions

      No notable interactions reported.

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)
      Other notes
      • ·Most research peptides are not FDA-approved for human use outside investigational protocols.

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      Topical 0.05–2% serum

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Systematic reviewBiomed Res Int · 2015

      GHK-Cu peptide in skin remodeling

      Pickart L, et al.

      Review of GHK-Cu in skin and wound healing.

      Key findings

      Promotes collagen synthesis and reduces wrinkles in topical use.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — Topical improves skin elasticity and wound healing

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) Topical improves skin elasticity and wound healing" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "Topical improves skin elasticity and wound healing". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — randomized controlled trial

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — meta-analysis

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — pharmacokinetics

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — safety adverse events

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: GHK-Cu (Copper Peptide) — dose response

      Live PubMed search

      Live results for "GHK-Cu (Copper Peptide) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching GHK-Cu (Copper Peptide) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: GHK-Cu (Copper Peptide) — clinical evidence

      Live Scholar search

      Cross-database citation index for GHK-Cu (Copper Peptide) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.