SYS ONLINE
SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

S-Equol

Daidzein metabolite for menopause.

Women's Health

Overview

Daidzein metabolite for menopause.

Natural sources
    Common forms

      Mechanism of action

      Selective ERβ agonist; potent estrogenic.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Reduces hot flashes

        Moderate evidence

        Potential side effects

        Common
        • · GI upset
        Rare
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            10 mg

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

            Compound
            S-Equol
            Amazon
            Wide selection · fast shipping
            Compound
            S-Equol
            iHerb
            Global delivery · curated brands
            Compound
            S-Equol
            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Womens Health · 2012

            S-equol in menopause

            Aso T, et al.

            160 women

            Key findings

            Reduced hot flash frequency.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — Reduces hot flashes

            Live PubMed search

            Live results for "S-Equol Reduces hot flashes" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "Reduces hot flashes". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — randomized controlled trial

            Live PubMed search

            Live results for "S-Equol randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — meta-analysis

            Live PubMed search

            Live results for "S-Equol meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — pharmacokinetics

            Live PubMed search

            Live results for "S-Equol pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — safety adverse events

            Live PubMed search

            Live results for "S-Equol safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: S-Equol — dose response

            Live PubMed search

            Live results for "S-Equol dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching S-Equol and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: S-Equol — clinical evidence

            Live Scholar search

            Cross-database citation index for S-Equol as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.