Overview
Daidzein metabolite for menopause.
- Endogenously produced or biosynthesized molecule
- Standardized pharmaceutical- or food-grade supplement
- Combined with cofactors that improve absorption or activity
- Capsule or softgel
- Powder
- Sublingual or buccal
- Liposomal liquid
Mechanism of action
Selective ERβ agonist; potent estrogenic.
- · Selective ERβ agonist
- · potent estrogenic
Effects on the body
Organ system effects
S-Equol has documented effects on female reproductive endocrinology and cycle regulation.
Evidence-based benefits
Reduces hot flashes
Moderate evidencePotential side effects
- · GI upset
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.
Third-party testedIndependently verified S-Equol — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.S-Equol third party tested NSF
CapsulesPre-measured S-Equol capsules — easiest for travel and consistent daily dosing without scoops or scales.S-Equol capsules
PowderBulk unflavored S-Equol powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.S-Equol powder unflavored
Best sellersMost-purchased S-Equol products on Amazon — a quick way to see what's reviewed widely before you commit.S-Equol best sellerScientific evidence8Show studiesHide studies
S-equol in menopause
Aso T, et al.
160 women
Reduced hot flash frequency.
PubMed: S-Equol — Reduces hot flashes
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PubMed: S-Equol — randomized controlled trial
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PubMed: S-Equol — meta-analysis
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PubMed: S-Equol — pharmacokinetics
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PubMed: S-Equol — safety adverse events
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PubMed: S-Equol — dose response
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Google Scholar: S-Equol — clinical evidence
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Cross-database citation index for S-Equol as it relates to "clinical evidence".
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