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SUPPLEMENT_SCHOLAR
evidence · mechanism · dose
Supplements/Compound

Hyaluronic Acid

aka HA · Sodium hyaluronate

Glycosaminoglycan supporting skin hydration and joint lubrication.

Skin, Hair & NailsJoint & Connective TissueEye Health

Overview

Glycosaminoglycan supporting skin hydration and joint lubrication.

Natural sources
  • Microbial fermentation
Common forms
  • Low MW HA (oral)
  • Topical HA
  • Intra-articular HA (Rx)

Mechanism of action

Holds water in extracellular matrix; intra-articular HA cushions joints.

Pathways
  • · ECM hydration

Effects on the body

Supports
Skin hydration
Supports
Joint comfort

Organ system effects

Skin

Improves hydration and elasticity.

Joints

IA injections reduce OA pain.

Evidence-based benefits

Improves skin hydration with oral 120–240 mg/d

Moderate evidence

Reduces knee OA pain

Moderate evidence

Potential side effects

Common
    Rare
      Serious

        Drug interactions

        No notable interactions reported.

        Supplement interactions

        Pairs well with

        None listed.

        Avoid combining with

        No specific avoidances listed.

        Dosing & bioavailability

        Typical dose
        120–240 mg/d oral

        Where to buy

        Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

        Compound
        Hyaluronic A…
        Amazon
        Wide selection · fast shipping
        Compound
        Hyaluronic A…
        iHerb
        Global delivery · curated brands
        Compound
        Hyaluronic A…
        Thorne
        Practitioner-grade · NSF tested

        Scientific evidence (9)

        RCTNutr J · 2016

        Oral hyaluronic acid for knee osteoarthritis

        Oe M, et al.

        12-month RCT of oral HA 200 mg/d in knee OA.

        Key findings

        Improved WOMAC pain and function vs placebo.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — Improves skin hydration with oral 120–240 mg/d

        Live PubMed search

        Live results for "Hyaluronic Acid Improves skin hydration with oral 120–240 mg/d" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "Improves skin hydration with oral 120–240 mg/d". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — Reduces knee OA pain

        Live PubMed search

        Live results for "Hyaluronic Acid Reduces knee OA pain" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "Reduces knee OA pain". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — randomized controlled trial

        Live PubMed search

        Live results for "Hyaluronic Acid randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — meta-analysis

        Live PubMed search

        Live results for "Hyaluronic Acid meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — pharmacokinetics

        Live PubMed search

        Live results for "Hyaluronic Acid pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — safety adverse events

        Live PubMed search

        Live results for "Hyaluronic Acid safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewPubMed (NLM) · 1970

        PubMed: Hyaluronic Acid — dose response

        Live PubMed search

        Live results for "Hyaluronic Acid dose response" across the PubMed/MEDLINE peer-reviewed index.

        Key findings

        Opens current human and preclinical literature matching Hyaluronic Acid and "dose response". Filter by RCT, meta-analysis, or year on the results page.

        Open study
        Systematic reviewGoogle Scholar · 1970

        Google Scholar: Hyaluronic Acid — clinical evidence

        Live Scholar search

        Cross-database citation index for Hyaluronic Acid as it relates to "clinical evidence".

        Key findings

        Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

        Open study
        Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.