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evidence · mechanism · dose
Supplements/Herb

Gymnema Sylvestre

Herb that blocks sweet taste perception and modestly lowers glucose.

Blood Sugar ManagementFat Loss

Overview

Herb that blocks sweet taste perception and modestly lowers glucose.

Natural sources
  • Gymnema sylvestre leaf
Common forms
  • Standardized gymnemic acids

Mechanism of action

Gymnemic acids block sugar receptors on taste buds and reduce intestinal glucose absorption.

Pathways
  • · Sweet receptor blockade
  • · Glucose absorption

Effects on the body

Decreases
Sweet cravings
Decreases
Postprandial glucose

Organ system effects

Evidence-based benefits

Reduces fasting glucose in T2D

Moderate evidence

Potential side effects

Common
    Rare
    • · Hypoglycemia
    Serious

      Drug interactions

      Antidiabetics
      Additive.
      moderate

      Safety & non-supplemental interactions

      Educational summary — always confirm with your clinician or pharmacist before starting, stopping, or combining with prescription therapy.

      Avoid if you are
      • ·Pregnant or breastfeeding (insufficient safety data)
      • ·Children under 18 (unless directed by a clinician)

      Supplement interactions

      Pairs well with

      None listed.

      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      200–400 mg standardized × 2/d

      Where to buy

      Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Herb
      Gymnema Sylv…
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      iHerb
      Global delivery · curated brands
      Herb
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      Thorne
      Practitioner-grade · NSF tested

      Scientific evidence (8)

      Systematic reviewJ Altern Complement Med · 2007

      Gymnema sylvestre for type 2 diabetes

      Leach MJ

      Review of Gymnema in diabetes.

      Key findings

      Improvements in fasting glucose and HbA1c.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — Reduces fasting glucose in T2D

      Live PubMed search

      Live results for "Gymnema Sylvestre Reduces fasting glucose in T2D" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "Reduces fasting glucose in T2D". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — randomized controlled trial

      Live PubMed search

      Live results for "Gymnema Sylvestre randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — meta-analysis

      Live PubMed search

      Live results for "Gymnema Sylvestre meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — pharmacokinetics

      Live PubMed search

      Live results for "Gymnema Sylvestre pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — safety adverse events

      Live PubMed search

      Live results for "Gymnema Sylvestre safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Gymnema Sylvestre — dose response

      Live PubMed search

      Live results for "Gymnema Sylvestre dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Gymnema Sylvestre and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Gymnema Sylvestre — clinical evidence

      Live Scholar search

      Cross-database citation index for Gymnema Sylvestre as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.