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Supplements/Compound

Stevia (Rebaudioside A)

Non-caloric sweetener that may improve glycemia and BP.

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Overview

Non-caloric sweetener that may improve glycemia and BP.

Natural sources
  • Endogenously produced or biosynthesized molecule
  • Standardized pharmaceutical- or food-grade supplement
  • Combined with cofactors that improve absorption or activity
Common forms
  • Capsule or softgel
  • Powder
  • Sublingual or buccal
  • Liposomal liquid

Mechanism of action

Steviol glycosides act as TRPM5 modulators and may improve β-cell function.

Pathways
  • · Steviol glycosides act as TRPM5 modulators
  • · may improve β-cell function

Effects on the body

Supports
Modest reduction in post-meal glucose

Organ system effects

Evidence-based benefits

Modest reduction in post-meal glucose

Moderate evidence

Potential side effects

Common
  • · Bitter aftertaste
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Stevia (Rebaudioside A) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      200–1000 mg/day stevioside
      Best form
      Most evidence is based on the capsule or softgel form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      With a meal containing fat for fat-soluble compounds; otherwise either.

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      RCTClin Ther · 2003

      Stevioside in hypertension

      Hsieh MH, et al.

      2-year DB-RCT in 174 HTN patients.

      Key findings

      Significant reduction in SBP/DBP vs placebo.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — Modest reduction in post-meal glucose

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) Modest reduction in post-meal glucose" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "Modest reduction in post-meal glucose". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — randomized controlled trial

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — meta-analysis

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — pharmacokinetics

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — safety adverse events

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Stevia (Rebaudioside A) — dose response

      Live PubMed search

      Live results for "Stevia (Rebaudioside A) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Stevia (Rebaudioside A) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Stevia (Rebaudioside A) — clinical evidence

      Live Scholar search

      Cross-database citation index for Stevia (Rebaudioside A) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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