Anti-Aging Skin
Wrinkles, elasticity, and pigmentation.
Ranked by evidence strength across reported benefits.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Vitamin A (Retinol)
Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Biotin (B7)
Coenzyme for carboxylases — popular for hair and nails despite weak data outside true deficiency.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Copper
Trace mineral cofactor for ceruloplasmin and connective tissue crosslinking.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Gotu Kola (Extra)
Standardized triterpenes for venous insufficiency and skin healing.
Marine Collagen (Extra)
Fish-derived type I collagen with high digestibility.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Copper Bisglycinate
Chelated copper used to balance high-dose zinc supplementation.
Zinc
Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
Collagen Peptides
Hydrolyzed protein supplying glycine, proline, and hydroxyproline for connective tissue.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
Hyaluronic Acid
Glycosaminoglycan supporting skin hydration and joint lubrication.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Hyaluronic Acid (Oral)
GAG concentrated in synovial fluid — improves joint comfort and skin hydration.
Astaxanthin
Algae-derived xanthophyll — most potent natural antioxidant; UV/eye/skin support.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Verisol® Collagen Peptides
Specific bovine peptide blend marketed for skin and cellulite.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Gotu Kola
Adaptogen used for cognitive support, anxiety, and wound healing.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
MSM (Methylsulfonylmethane)
Bioavailable sulfur donor for joints, skin, and hair-keratin synthesis.
Marine Collagen Peptides
Hydrolyzed fish collagen — supplies glycine, proline, and bioactive di/tripeptides for skin and hair.
TUDCA (Tauroursodeoxycholic Acid)
Conjugated bile acid — hepatoprotective and ER-stress-reducing.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
Niacinamide
Non-flushing B3 — used for deficiency, skin health, and at high doses in dermatology.
Biotin (Hair Dose)
B-vitamin used cosmetically for hair and nail growth.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Saw Palmetto
Lipidosterolic extract used for BPH urinary symptoms.
Spearmint Tea
Used for hirsutism in PCOS via mild anti-androgen effect.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
GHK-Cu (Copper Peptide)
Copper-binding tripeptide used topically for skin remodeling.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.
Curcumin Phytosome (Meriva)
Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
Centella asiatica (Skin)
Standardized titrated extract for scars and venous skin changes.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Urolithin A (Mitopure)
Gut-derived ellagitannin metabolite that induces mitophagy.
Glycine (Collagen Stack)
Free-form glycine paired with collagen for connective tissue synthesis.
Zinc Bisglycinate (High-Bio)
Chelated zinc with superior absorption and tolerability.
Choline-Stabilized Orthosilicic Acid (ch-OSA)
Highly bioavailable silica for hair, skin, and bone.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Centella Triterpene Fraction
Standardized madecassoside/asiaticoside for skin and venous health.
TB-500 (Thymosin Beta-4)
Synthetic thymosin fragment for tissue repair.
Epitalon
Tetrapeptide that activates telomerase.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Glycine + NAC (GlyNAC)
Glutathione-boosting combination for aging.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
Squalene
Olive oil/shark liver lipid antioxidant.
L-Lysine
Essential amino acid for collagen and HSV prevention.
Bamboo Silica
Plant-based silicon for skin and bones.
Choline-Stabilized OSA
Bioavailable silicon form.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Astaxanthin (Haematococcus)
Algae carotenoid antioxidant.
Tremella Fuciformis
Snow fungus for skin hydration.
DMAE (Dimethylaminoethanol)
Choline analog for cognition.
Type III Collagen
Skin and vascular collagen.
Marine Collagen Peptides
Fish-derived collagen.
Bovine Collagen Peptides
Cow-derived collagen hydrolysate.
Hyaluronic Acid (Oral)
Oral HA for skin and joints.
OptiMSM
Distilled MSM for joints.
Biotin (High-Dose)
High-dose for MS and hair.
MSM (Methylsulfonylmethane)
Organic sulfur for joints and skin.
Grape Seed Extract
Vitis vinifera procyanidins.
Trans-Resveratrol
Active form of resveratrol.
Micronized Resveratrol
Improved bioavailability resveratrol.
Punicalagin
Major pomegranate ellagitannin.
Ellagic Acid
Ellagitannin hydrolysis product.
Manuka Honey
Leptospermum honey with MGO.
Honokiol
Active magnolia compound.
Liposomal Vitamin C
Phospholipid-encapsulated vitamin C.
Ascorbyl Palmitate
Fat-soluble vitamin C ester.
Oleocanthal
EVOO ibuprofen-like compound.
Evening Primrose Oil
GLA omega-6 for skin and PMS.
Borage Oil
Highest GLA content.
Blackcurrant Seed Oil
GLA + ALA omega-3/6.
Hemp Seed Oil
3:1 omega-6 to omega-3 ratio.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Vitamin B7 (Biotin)
Carboxylase cofactor marketed for hair, skin, and nail support.
Evening Primrose Oil
Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Quercetin
Flavonoid with antihistamine, anti-viral, and senolytic activity.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Vitamin B5 (Pantothenic acid)
Component of coenzyme A, central to fatty acid and acetylcholine synthesis.
Silica (Silicon)
Trace element involved in collagen and connective tissue crosslinking.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
Horsetail Extract
Silica-rich herb traditionally used for hair, nail, and connective tissue support.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Spermidine
Polyamine that induces autophagy — emerging longevity supplement.
Zinc Picolinate
Zinc chelated to picolinic acid — one of the most bioavailable oral forms.
Zinc Bisglycinate
Glycine-chelated zinc — high absorption and very gentle on the stomach.
Liposomal Glutathione
Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.
S-Acetyl Glutathione
Acetylated GSH — stable through the gut and converted intracellularly to glutathione.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Quercetin + Dasatinib (D+Q)
Reference senolytic combination cycled to clear senescent cells.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.
Biotinyl Tripeptide-1 (Procapil)
Topical peptide complex marketed for hair anchoring.