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Zinc Deficiency

Immunity, skin, and taste implications.

Ranked by evidence strength across reported benefits.

Vitamin#1· strong

Vitamin D3

Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.

Amino Acid#2· strong

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Vitamin#3· strong

Vitamin A (Retinol)

Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.

Vitamin#4· strong

Vitamin C

Water-soluble antioxidant, collagen cofactor, and immune supporter.

Herb#5· strong

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Compound#6· strong

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Compound#7· strong

Beta-Glucan

Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).

Vitamin#8· strong

Vitamin D3 (Cholecalciferol)

Preferred form for raising 25(OH)D — the active form your skin makes from sun.

Herb#9· strong

Aged Garlic Extract (Kyolic)

Odorless aged garlic with S-allyl-cysteine for vascular health.

Mushroom#10· strong

Turkey Tail

Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).

Compound#11· strong

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Herb#12· strong

Andrographis

Bitter herb with strong RCT evidence for URI symptom reduction.

Mineral#13· strong

Zinc Gluconate

Most common over-the-counter zinc form — affordable, moderate bioavailability.

Herb#14· strong

Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

Herb#15· strong

Pelargonium sidoides (Umckaloabo)

South African geranium root for acute bronchitis and URIs.

Vitamin#16· strong

Vitamin D3 (Maintenance)

Daily maintenance dose for non-deficient adults.

Vitamin#17· strong

Vitamin D3 (Repletion)

Repletion dose for deficiency under medical supervision.

Mineral#18· strong

Selenium-Enriched Yeast

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Herb#19· moderate

Tongkat Ali

Malaysian root extract that frees bound testosterone via SHBG reduction.

Mineral#20· moderate

Zinc

Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.

Amino Acid#21· moderate

L-Glutamine

Most abundant amino acid; primary fuel for enterocytes and immune cells.

Herb#22· moderate

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Herb#23· moderate

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Compound#24· moderate

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound#25· moderate

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Herb#26· moderate

Tongkat Ali (Eurycoma longifolia)

Malaysian root with moderate human evidence for raising free testosterone and reducing SHBG.

Compound#27· moderate

Yohimbine

Alpha-2 antagonist — improves erection and fat loss in fasted state but cardiovascular caution.

Compound#28· moderate

Shilajit

Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.

Mushroom#29· moderate

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Compound#30· moderate

DIM (Diindolylmethane)

Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.

Compound#31· moderate

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Herb#32· moderate

Saw Palmetto

5α-reductase-inhibiting berry extract — used for BPH and androgenic hair loss.

Compound#33· moderate

DIM (Diindolylmethane)

Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.

Mineral#34· moderate

Selenium

Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

Mushroom#35· moderate

Cordyceps

Medicinal fungus studied for aerobic capacity and immune modulation.

Mushroom#36· moderate

Shiitake (Lentinan)

Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.

Herb#37· moderate

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Herb#38· moderate

Saw Palmetto

Lipidosterolic extract used for BPH urinary symptoms.

Herb#39· moderate

Pygeum

African plum bark used for BPH urinary symptoms.

Herb#40· moderate

Stinging Nettle Root

Herbal for BPH and SHBG modulation, often paired with saw palmetto.

Compound#41· moderate

Bifidobacterium Probiotics

Dominant probiotic genus in the colon; supports immune and gut barrier.

Herb#42· moderate

Elderberry

Anthocyanin-rich berry used to shorten influenza and URI symptoms.

Herb#43· moderate

Echinacea

Native American herb used for URI prevention/duration reduction.

Herb#44· moderate

Cranberry

Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.

Herb#45· moderate

Panax Ginseng (Sexual Health)

Korean red ginseng with RCT-level evidence for erectile dysfunction.

Mineral#46· moderate

Zinc (Sperm Health)

Concentrated in semen — essential for sperm production and testosterone.

Herb#47· moderate

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Mineral#48· moderate

Zinc (Immune Use)

Lozenges started within 24h of symptom onset shorten colds ~33%.

Mineral#49· moderate

Zinc Acetate

Lozenge form shown to shorten cold duration when used at first symptoms.

Compound#50· moderate

Lycopene

Tomato carotenoid linked with prostate and cardiovascular protection.

Mushroom#51· moderate

Agaricus blazei

Brazilian mushroom rich in β-glucans for immune modulation.

Mushroom#52· moderate

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Compound#53· moderate

Spirulina (Extra Profile)

Cyanobacterium with phycocyanin for allergy and immunity.

Mineral#54· moderate

Zinc Bisglycinate (High-Bio)

Chelated zinc with superior absorption and tolerability.

Mineral#55· moderate

Boron (Extra)

Trace mineral that modulates steroid hormones and bone.

Herb#56· moderate

Butterbur

Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.

Herb#57· moderate

Cat's Claw

Uncaria tomentosa for joint pain and immunity.

Mushroom#58· moderate

Agaricus Blazei

Brazilian sun mushroom for immune support.

Mushroom#59· moderate

Phellinus Linteus

Meshima mushroom with hispolon for immune support.

Herb#60· moderate

Mucuna Pruriens

Velvet bean providing natural L-DOPA.

Compound#61· moderate

PEA (Palmitoylethanolamide)

Endogenous fatty acid amide for pain and inflammation.

Amino Acid#62· moderate

L-Lysine

Essential amino acid for collagen and HSV prevention.

Mineral#63· moderate

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Compound#64· moderate

Quercetin Phytosome

Lecithin-complexed quercetin.

Compound#65· moderate

Quercetin + Bromelain

Anti-inflammatory pair for allergies.

Herb#66· moderate

Nettle Root

Urtica dioica for BPH.

Compound#67· moderate

Beta-Sitosterol

Plant sterol for BPH and cholesterol.

Herb#68· moderate

Stinging Nettle Leaf

Urtica dioica leaf for allergies and joint pain.

Compound#69· moderate

Isoquercetin

Highly bioavailable quercetin glycoside.

Compound#70· moderate

Luteolin

Flavone with anti-inflammatory effects.

Compound#71· moderate

Baicalin

Scutellaria baicalensis flavonoid.

Herb#72· moderate

Pelargonium Sidoides

South African geranium for bronchitis.

Herb#73· moderate

EPs 7630

Standardized Pelargonium extract.

Herb#74· moderate

Echinacea Purpurea

Coneflower for upper respiratory infections.

Herb#75· moderate

Echinacea Angustifolia

Narrow-leaf coneflower for immune support.

Herb#76· moderate

Black Maca

Lepidium meyenii black variant for energy.

Herb#77· moderate

Red Maca

Lepidium meyenii red variant for prostate.

Mushroom#78· moderate

Lion's Mane Fruiting Body

Hericinones-rich beta-glucan source.

Mushroom#79· moderate

Agarikon (Fomitopsis officinalis)

Antiviral polypore mushroom.

Mushroom#80· moderate

Poria Cocos

TCM mushroom for sleep and immunity.

Mushroom#81· moderate

Oyster Mushroom

Pleurotus ostreatus with ergothioneine.

Herb#82· moderate

Butterbur Ze 339

PA-free butterbur for allergic rhinitis.

Herb#83· moderate

Marshmallow Root

Althaea officinalis mucilage for cough.

Compound#84· moderate

Pomegranate Extract

Punica granatum ellagitannins.

Herb#85· moderate

Cranberry Extract

Vaccinium macrocarpon for UTI prevention.

Herb#86· moderate

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Fatty Acid#87· moderate

Lauric Acid

Coconut MCFA with antimicrobial activity.

Fatty Acid#88· moderate

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Compound#89· moderate

Thymoquinone

Active black seed compound.

Compound#90· moderate

Propolis

Bee glue with caffeic acid phenethyl ester.

Compound#91· moderate

Bee Pollen

Pollen collected by bees.

Compound#92· moderate

Manuka Honey

Leptospermum honey with MGO.

Compound#93· moderate

Bromelain

Pineapple proteolytic enzyme.

Herb#94· moderate

Tongkat Ali Eurycomanone-Standardized

LJ100 standardized to 22% eurypeptides.

Herb#95· moderate

Stinging Nettle Root

Urtica dioica root for free testosterone.

Mineral#96· moderate

Boron Citrate

Boron for hormone modulation.

Mineral#97· moderate

Zinc Monomethionine (ZMA)

Zinc + magnesium + B6 for recovery.

Herb#98· moderate

Ginger Extract (Zingiber)

Standardized ginger for nausea and inflammation.

Herb#99· moderate

Galangal (Alpinia)

Thai ginger relative for inflammation.

Herb#100· moderate

Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

Compound#101· moderate

Holy Basil Eugenol

Active constituent of tulsi.

Vitamin#102· moderate

Liposomal Vitamin C

Phospholipid-encapsulated vitamin C.

Vitamin#103· moderate

Ascorbyl Palmitate

Fat-soluble vitamin C ester.

Vitamin#104· moderate

Sodium Ascorbate

Buffered vitamin C form.

Compound#105· moderate

Bovine Colostrum

First milk with growth factors.

Compound#106· moderate

Chlorella

Green algae with chlorophyll.

Herb#107· moderate

Amla (Indian Gooseberry)

Phyllanthus emblica vitamin C source.

Fatty Acid#108· moderate

Black Cumin Seed Oil

Nigella sativa oil.

Herb#109· limited

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Compound#110· limited

Pumpkin Seed Oil

Cold-pressed seed oil studied for hair density and prostate health.

Mineral#111· limited

Boron

Trace mineral with modest effects on free testosterone and bone mineralization.

Compound#112· limited

Quercetin

Flavonoid with antihistamine, anti-viral, and senolytic activity.

Herb#113· limited

Fadogia Agrestis

Nigerian shrub — popularized for testosterone support; sparse human data.

Mushroom#114· limited

Chaga

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Compound#115· limited

Monolaurin

Coconut-derived monoglyceride with antimicrobial properties against enveloped viruses.

Vitamin#116· limited

Vitamin C (Harm-Reduction Antioxidant)

Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.

Herb#117· limited

Horny Goat Weed (Epimedium)

Icariin-rich herb with PDE5-inhibitor-like activity for erectile function.

Mineral#118· limited

Zinc Picolinate

Zinc chelated to picolinic acid — one of the most bioavailable oral forms.

Mineral#119· limited

Zinc Bisglycinate

Glycine-chelated zinc — high absorption and very gentle on the stomach.

Compound#120· limited

Liposomal Glutathione

Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

Herb#121· limited

Chinese Skullcap

Flavonoid-rich root used for anxiety and inflammation.

Herb#122· limited

Pine Pollen

Phyto-androgen pollen containing trace testosterone and DHEA.

Peptide#123· limited

Thymulin (Reference)

Zinc-dependent thymic peptide that matures T-cells.

Herb#124· limited

Topical Saw Palmetto

Topical lotion form for androgenetic alopecia.

Mineral#125· limited

Calcium AEP (Membrane Calcium)

Cell-membrane-targeted form of calcium claimed for autoimmune support.

Herb#126· limited

Fadogia Agrestis

African shrub touted for testosterone (rodent data only).

Herb#127· anecdotal

Fadogia Agrestis

African shrub popularized for testosterone; limited human data and toxicology concerns.