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Supplements/Mineral

Zinc (Immune Use)

Lozenges started within 24h of symptom onset shorten colds ~33%.

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Overview

Lozenges started within 24h of symptom onset shorten colds ~33%.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Mechanism of action

Free Zn²⁺ in throat inhibits rhinovirus 3C protease and ICAM-1 binding.

Pathways
  • · Free Zn²⁺ in throat inhibits rhinovirus 3C protease
  • · ICAM-1 binding

Effects on the body

Decreases
cold duration if started early

Organ system effects

Evidence-based benefits

Reduces cold duration if started early

Moderate evidence

Potential side effects

Common
  • · Bad taste
Rare
    Serious

      Drug interactions

      Prescription medications (general)
      Always disclose Zinc (Immune Use) use to your prescriber — additive, antagonistic, or pharmacokinetic interactions are possible.
      minor

      Supplement interactions

      Pairs well with
      • A high-quality multivitamin
        Covers micronutrient cofactors that support most supplement pathways.
      • Omega-3 (EPA/DHA)
        Foundational anti-inflammatory support that complements most regimens.
      Avoid combining with

      No specific avoidances listed.

      Dosing & bioavailability

      Typical dose
      75 mg/d divided across lozenges × ≤7 days
      Best form
      Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
      Timing
      Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
      With food?
      Lozenge, not swallowed

      Where to buy

      Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

      Scientific evidence8Show studies
      Meta-analysisJRSM Open · 2017

      Zinc lozenges and the common cold

      Hemilä H

      Meta-analysis of zinc-acetate lozenge RCTs.

      Key findings

      Shortened cold duration by ~33%.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — Reduces cold duration if started early

      Live PubMed search

      Live results for "Zinc (Immune Use) Reduces cold duration if started early" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "Reduces cold duration if started early". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — randomized controlled trial

      Live PubMed search

      Live results for "Zinc (Immune Use) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — meta-analysis

      Live PubMed search

      Live results for "Zinc (Immune Use) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — pharmacokinetics

      Live PubMed search

      Live results for "Zinc (Immune Use) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — safety adverse events

      Live PubMed search

      Live results for "Zinc (Immune Use) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewPubMed (NLM) · 1970

      PubMed: Zinc (Immune Use) — dose response

      Live PubMed search

      Live results for "Zinc (Immune Use) dose response" across the PubMed/MEDLINE peer-reviewed index.

      Key findings

      Opens current human and preclinical literature matching Zinc (Immune Use) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

      Open study
      Systematic reviewGoogle Scholar · 1970

      Google Scholar: Zinc (Immune Use) — clinical evidence

      Live Scholar search

      Cross-database citation index for Zinc (Immune Use) as it relates to "clinical evidence".

      Key findings

      Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

      Open study
      Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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