Women's Longevity
Female-specific aging concerns.
Ranked by evidence strength across reported benefits.
Melatonin
Pineal hormone that signals biological night — most effective for circadian-rhythm shifts.
Coffee
Caffeine + polyphenol matrix with strong evidence for mortality and T2D reduction.
N-Acetyl Cysteine (NAC)
Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.
Ginger
Culinary rhizome with strong antiemetic and anti-inflammatory effects.
Vitamin B3 (Niacin)
NAD+ precursor; nicotinic acid form lowers LDL and raises HDL.
Saffron
Culinary spice with antidepressant effects comparable to SSRIs in mild-moderate depression.
Vitamin C
Water-soluble antioxidant, collagen cofactor, and immune supporter.
Vitamin B6 (Pyridoxine)
Cofactor for >100 enzymes including neurotransmitter synthesis.
Folate (Vitamin B9)
One-carbon donor essential for DNA synthesis and neural tube development.
Iron
Oxygen-carrying mineral central to hemoglobin and cellular respiration.
Milk Thistle
Hepatoprotective herb with antioxidant and anti-fibrotic effects.
Garlic
Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.
Chasteberry (Vitex)
Dopaminergic herb reducing prolactin and improving PMS/luteal phase symptoms.
Myo-Inositol
Insulin sensitizer used for PCOS and anxiety/OCD support.
Lactobacillus Probiotics
Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.
Glycine
Inhibitory amino acid that improves sleep quality, glycemic control, and collagen synthesis.
Methylfolate (L-5-MTHF)
Bioactive folate that bypasses the MTHFR enzyme — preferred in MTHFR variants and pregnancy.
Tribulus terrestris (Libido)
Steroidal saponin herb claimed for libido and sexual function.
Nicotinamide Riboside (NR)
NAD+ precursor with bioavailability and longevity research interest.
NMN
NAD+ precursor similar to NR; bioavailability route debated.
Nicotinamide Riboside (NR)
NAD+ precursor that bypasses the flush — studied for cellular aging.
Alpha-Lipoic Acid
Mitochondrial antioxidant studied for diabetic neuropathy and insulin sensitivity.
Ferrous Sulfate
Standard low-cost iron salt — effective but commonly causes GI side effects.
Idebenone
Synthetic CoQ10 analog with better water solubility; used in LHON.
Selenium-Enriched Yeast
Yeast-bound selenomethionine — form used in major chemoprevention trials.
DHA (Prenatal)
Critical fatty acid for fetal brain and retinal development.
ALA (R-isomer)
Natural enantiomer of α-lipoic acid with better bioavailability.
Vitamin K2 (MK-7)
Activates the proteins that direct calcium into bone — not arteries.
Coenzyme Q10
Mitochondrial electron carrier and lipid-soluble antioxidant.
Maca
Andean root associated with libido improvement and energy without hormone changes.
Glycine
Inhibitory neurotransmitter that improves sleep quality and supports collagen synthesis.
Vitamin E
Primary lipid-phase antioxidant protecting membrane PUFAs.
Pomegranate
Polyphenol-rich fruit converted by gut microbes to urolithin A (mitochondrial benefit).
Green Tea (EGCG)
Polyphenol-rich tea; EGCG modestly boosts metabolism and supports cardiovascular health.
DHEA
Adrenal androgen precursor declining with age; used for adrenal insufficiency and aging.
Soy Isoflavones
Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.
Astaxanthin
Algal carotenoid that is the strongest membrane antioxidant; UV and eye protection.
Alpha-Lipoic Acid (ALA)
Universal antioxidant that's both water and fat soluble — supports glycemic control and nerve health.
Myo-Inositol
Insulin-sensitizing sugar alcohol — first-line non-Rx option for PCOS.
Ubiquinol (CoQ10)
Reduced active form of CoQ10 — preferred in adults over 40 and those with statin-induced depletion.
Vitamin K2 (MK-7)
Long-half-life K2 — directs calcium to bone and away from arteries.
Astaxanthin (Eye dose)
Carotenoid that crosses BBB and accumulates in ciliary body.
Taurine
Conditionally essential amino acid involved in bile salt conjugation, osmoregulation, and cardiac function.
Glutathione
Master intracellular antioxidant; oral bioavailability depends on form.
TUDCA
Bile acid with hepatoprotective effects and ER stress reduction.
Ginkgo Biloba
Vasoactive herb studied for cognition in the elderly and tinnitus.
Shilajit
Himalayan mineral exudate rich in fulvic acid, studied for testosterone and fatigue.
Reishi
Adaptogenic mushroom used for immune balance, sleep, and stress.
DIM (Diindolylmethane)
Cruciferous-derived compound modulating estrogen metabolism toward 2-OH pathway.
Quercetin
Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.
TUDCA (Tauroursodeoxycholic Acid)
Conjugated bile acid — hepatoprotective and ER-stress-reducing.
Resveratrol
Polyphenol from grapes — sirtuin activator with mixed human evidence.
Taurine
Conditionally essential amino acid with cardiovascular, metabolic, and longevity effects.
DIM (Diindolylmethane)
Cruciferous-vegetable metabolite that shifts estrogen metabolism toward 2-OH (protective) pathways.
Chasteberry (Vitex)
Dopaminergic herb that lowers prolactin and supports luteal-phase progesterone.
Magnesium L-Threonate
Magnesium bound to L-threonic acid — the only form shown to meaningfully raise brain magnesium.
P-5-P (Pyridoxal-5-Phosphate)
Active coenzyme form of B6 — preferred over pyridoxine HCl for sensitive populations.
NMN (Nicotinamide Mononucleotide)
Direct NAD+ precursor — popular longevity supplement with growing human data.
Taurine (High-Dose)
Conditionally essential amino acid with longevity and metabolic effects.
Calcium
Major bone mineral; also critical for muscle contraction and nerve signaling.
Selenium
Trace mineral essential for glutathione peroxidase and thyroid hormone activation.
Black Cohosh
Standardized extract for menopausal vasomotor symptoms.
Spearmint Tea
Used for hirsutism in PCOS via mild anti-androgen effect.
Krill Oil
Phospholipid-bound omega-3 with astaxanthin; better bioavailability than fish oil per gram.
Resveratrol
Polyphenol activating sirtuins; bioavailability and clinical effects modest.
Cranberry
Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.
D-Mannose
Simple sugar that binds E. coli fimbriae, flushing them from the urinary tract.
Urolithin A
Gut-microbial metabolite of ellagitannins — induces mitophagy.
Black Cohosh
Phytotherapy for menopausal vasomotor symptoms — non-estrogenic but symptom-active.
Curcumin Phytosome (Meriva)
Phosphatidylcholine-complexed curcumin — ~29× higher bioavailability than standard extract.
Iron Bisglycinate
Chelated ferrous iron — best-tolerated form with high absorption and minimal GI distress.
Selenomethionine
Organic selenium form — preferred for thyroid (Hashimoto's) and antioxidant support.
Pterostilbene (Extra)
Methylated resveratrol analog with superior bioavailability.
Tocotrienols (Skin/Aging)
Vitamin E isoforms with 40–60× higher antioxidant power than tocopherols.
Trans-Resveratrol (Pure)
Purified active isomer of resveratrol.
Spermidine (Wheat Germ)
Polyamine that induces autophagy and may extend lifespan.
Urolithin A (Mitopure)
Gut-derived ellagitannin metabolite that induces mitophagy.
Mixed Tocopherols
Full-spectrum natural vitamin E avoiding α-only supplementation pitfalls.
Epitalon
Tetrapeptide that activates telomerase.
MOTS-c
Mitochondrial-derived peptide for metabolic regulation.
SS-31 (Elamipretide)
Mitochondrial-targeted peptide for cardiolipin protection.
Glycine + NAC (GlyNAC)
Glutathione-boosting combination for aging.
Rapamycin
mTOR inhibitor studied for longevity (Rx only).
Metformin (Longevity Use)
Biguanide diabetes drug studied for healthspan.
Myo-Inositol
Insulin sensitizer for PCOS and metabolic health.
MitoQ
Mitochondria-targeted ubiquinone (CoQ10 analog).
PQQ (Pyrroloquinoline Quinone)
Redox cofactor for mitochondrial biogenesis.
C60 in Olive Oil
Buckminsterfullerene antioxidant.
Ergothioneine (Mushroom-Derived)
Natural ergothioneine from oyster mushrooms.
Hydroxytyrosol
Olive polyphenol for cardiovascular health.
Selenium (Selenomethionine)
Antioxidant trace element for thyroid.
Chaste Tree (Vitex)
Vitex agnus-castus for PMS.
Genistein
Soy isoflavone with bone benefits.
S-Equol
Daidzein metabolite for menopause.
Trans-Resveratrol
Active form of resveratrol.
Micronized Resveratrol
Improved bioavailability resveratrol.
Punicalagin
Major pomegranate ellagitannin.
Ellagic Acid
Ellagitannin hydrolysis product.
Cranberry Extract
Vaccinium macrocarpon for UTI prevention.
Royal Jelly
Queen bee secretion with 10-HDA.
Honokiol
Active magnolia compound.
Oleocanthal
EVOO ibuprofen-like compound.
Evening Primrose Oil
GLA omega-6 for skin and PMS.
Lion's Mane
Edible medicinal mushroom that upregulates NGF and BDNF — studied for nerve growth and cognition.
Evening Primrose Oil
Omega-6 source rich in GLA, used for atopic dermatitis and cyclical breast pain.
Fisetin
Flavonoid studied as senolytic — clearing senescent cells in animal models.
Quercetin
Flavonoid with antihistamine, anti-viral, and senolytic activity.
Shatavari
Ayurvedic adaptogen used for female hormone balance and lactation support.
Tocotrienols (Vitamin E)
Unsaturated vitamin E family — superior antioxidant capacity vs alpha-tocopherol.
Lithium Orotate (low-dose)
Low-dose lithium salt studied for mood stability and neuroprotection.
Chaga
Birch-tree mushroom rich in melanin, betulin, and antioxidants.
Dong Quai
TCM herb traditionally used for menstrual and menopausal symptoms.
Red Clover
Isoflavone-rich legume traditionally used for menopausal symptoms.
PQQ
Cofactor stimulating mitochondrial biogenesis (PGC-1α).
Pterostilbene
Bioavailable resveratrol analog with longer half-life.
Spermidine
Polyamine inducing autophagy; epidemiologic association with longevity.
Uva-Ursi
Antibacterial herb for acute uncomplicated UTI; alkaline urine required.
Marine Protein Complex (AminoMar)
Proprietary marine-derived complex (AminoMar) clinically studied for thinning hair in women.
ALCAR + ALA (Mitochondrial Protection)
Mitochondrial antioxidant stack — popularized as harm-reduction adjunct for MDMA neuroprotection.
EGCG (Green Tea Catechin)
Potent CYP/COMT-modulating antioxidant — popularized in MDMA harm-reduction stacks.
Pterostilbene
Methylated analog of resveratrol — better bioavailability and longer half-life.
Spermidine
Polyamine that induces autophagy — emerging longevity supplement.
Liposomal Glutathione
Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.
S-Acetyl Glutathione
Acetylated GSH — stable through the gut and converted intracellularly to glutathione.
9-Me-BC
β-carboline alkaloid that upregulates dopamine neurons in animal models.
Centrophenoxine
Cholinergic precursor that reduces lipofuscin accumulation in neurons.
Thymulin (Reference)
Zinc-dependent thymic peptide that matures T-cells.
Alpha-Ketoglutarate (AKG)
TCA-cycle intermediate studied for healthspan and frailty.
Fisetin (Senolytic)
Polyphenol senolytic with neuroprotective and anti-inflammatory effects.
Quercetin + Dasatinib (D+Q)
Reference senolytic combination cycled to clear senescent cells.
L-Carnosine
Dipeptide that buffers protons and reduces advanced glycation end-products.
Ergothioneine (Extra)
Unique thiol antioxidant concentrated in mitochondria via OCTN1.