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Vitamin D Deficiency

Bone, immune, and mood implications.

Ranked by evidence strength across reported benefits.

Mineral#1· strong

Magnesium

Essential cofactor in 300+ enzymatic reactions, from ATP production to muscle relaxation.

Vitamin#2· strong

Vitamin D3

Steroid hormone precursor regulating ~5% of the human genome — bone, immune, and hormonal health.

Amino Acid#3· strong

N-Acetyl Cysteine (NAC)

Glutathione precursor with mucolytic, hepatoprotective, and psychiatric uses.

Vitamin#4· strong

Vitamin A (Retinol)

Fat-soluble vitamin essential for vision, immune function, and epithelial integrity.

Vitamin#5· strong

Vitamin C

Water-soluble antioxidant, collagen cofactor, and immune supporter.

Herb#6· strong

Garlic

Culinary bulb with cardiovascular benefits primarily via allicin and aged-garlic compounds.

Compound#7· strong

Lactobacillus Probiotics

Lactic acid bacteria supporting gut barrier, immunity, and women's urogenital health.

Compound#8· strong

Beta-Glucan

Polysaccharide that primes innate immune cells (yeast) or lowers cholesterol (oat).

Vitamin#9· strong

Vitamin D3 (Cholecalciferol)

Preferred form for raising 25(OH)D — the active form your skin makes from sun.

Herb#10· strong

Aged Garlic Extract (Kyolic)

Odorless aged garlic with S-allyl-cysteine for vascular health.

Mushroom#11· strong

Turkey Tail

Beta-glucan-rich mushroom used as immune adjunct in cancer (PSK approved in Japan).

Compound#12· strong

Saccharomyces Boulardii

Beneficial yeast used to prevent and treat several types of diarrhea.

Herb#13· strong

Andrographis

Bitter herb with strong RCT evidence for URI symptom reduction.

Mineral#14· strong

Strontium

Trace element that displaces Ca in bone and was approved (ranelate) for osteoporosis.

Mineral#15· strong

Potassium Citrate

Alkalinizing K salt used for kidney stone prevention and bone health.

Mineral#16· strong

Calcium Citrate

Best-absorbed calcium salt — does not require stomach acid.

Mineral#17· strong

Zinc Gluconate

Most common over-the-counter zinc form — affordable, moderate bioavailability.

Vitamin#18· strong

Vitamin D2 (Ergocalciferol)

Plant-derived prescription D — high doses (50,000 IU) used for rapid deficiency correction.

Herb#19· strong

Andrographis (KalmCold)

Standardized andrographolide for acute upper respiratory infections.

Herb#20· strong

Pelargonium sidoides (Umckaloabo)

South African geranium root for acute bronchitis and URIs.

Vitamin#21· strong

Vitamin D3 (Maintenance)

Daily maintenance dose for non-deficient adults.

Vitamin#22· strong

Vitamin D3 (Repletion)

Repletion dose for deficiency under medical supervision.

Mineral#23· strong

Selenium-Enriched Yeast

Yeast-bound selenomethionine — form used in major chemoprevention trials.

Mineral#24· strong

Strontium Ranelate (Ref)

Reference strontium salt used as anti-osteoporotic drug.

Vitamin#25· strong

Vitamin K1 (Phylloquinone)

Leafy-green K1 essential for hepatic coagulation factors.

Mineral#26· moderate

Zinc

Cofactor for ~300 enzymes — critical for testosterone, immune function, and DNA synthesis.

Vitamin#27· moderate

Vitamin K2 (MK-7)

Activates the proteins that direct calcium into bone — not arteries.

Amino Acid#28· moderate

L-Glutamine

Most abundant amino acid; primary fuel for enterocytes and immune cells.

Compound#29· moderate

Collagen Peptides

Hydrolyzed protein supplying glycine, proline, and hydroxyproline for connective tissue.

Herb#30· moderate

American Ginseng

Cooler adaptogen with stronger evidence for blood sugar and cold-flu prevention.

Compound#31· moderate

Soy Isoflavones

Phytoestrogens with mild SERM effects on bone, hot flashes, and lipids.

Herb#32· moderate

Licorice Root

Adrenal-supporting herb; chronic high-dose causes pseudo-aldosteronism.

Compound#33· moderate

Bovine Colostrum

First milk rich in IgG, lactoferrin, and growth factors for immune and gut support.

Compound#34· moderate

Lactoferrin

Iron-binding protein with antimicrobial and immunomodulating effects.

Vitamin#35· moderate

Vitamin K2 (MK-7)

Long-half-life K2 — directs calcium to bone and away from arteries.

Mushroom#36· moderate

Reishi

Adaptogenic mushroom used for immune balance, sleep, and stress.

Compound#37· moderate

Quercetin

Flavonoid with antihistamine and senolytic effects; pairs with bromelain or vitamin C.

Vitamin#38· moderate

Vitamin D3 + K2 Synergy Note

Combined fat-soluble vitamins addressing calcium destination (bone vs artery).

Mineral#39· moderate

Calcium

Major bone mineral; also critical for muscle contraction and nerve signaling.

Mineral#40· moderate

Selenium

Trace mineral essential for glutathione peroxidase and thyroid hormone activation.

Mineral#41· moderate

Manganese

Trace mineral cofactor for SOD, gluconeogenesis, and bone formation.

Mushroom#42· moderate

Cordyceps

Medicinal fungus studied for aerobic capacity and immune modulation.

Mushroom#43· moderate

Shiitake (Lentinan)

Culinary mushroom whose beta-glucan lentinan is an approved injectable immune adjunct.

Herb#44· moderate

Olive Leaf Extract

Mediterranean herb with antihypertensive and immune effects.

Compound#45· moderate

Bifidobacterium Probiotics

Dominant probiotic genus in the colon; supports immune and gut barrier.

Herb#46· moderate

Elderberry

Anthocyanin-rich berry used to shorten influenza and URI symptoms.

Herb#47· moderate

Echinacea

Native American herb used for URI prevention/duration reduction.

Herb#48· moderate

Cranberry

Berry with PACs that inhibit E. coli adhesion to urothelium for UTI prevention.

Herb#49· moderate

Aged Garlic Extract (Kyolic)

Standardized aged garlic — modest BP and cholesterol benefits.

Mineral#50· moderate

Strontium Citrate

Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

Mineral#51· moderate

Zinc Acetate

Lozenge form shown to shorten cold duration when used at first symptoms.

Vitamin#52· moderate

Vitamin K2 (MK-4)

Short-acting K2 form used at high dose in Japanese osteoporosis protocols.

Compound#53· moderate

Icariin (Horny Goat Weed)

Active flavonoid from Epimedium acting as PDE5 inhibitor.

Mushroom#54· moderate

Agaricus blazei

Brazilian mushroom rich in β-glucans for immune modulation.

Mushroom#55· moderate

Maitake D-Fraction

Standardized β-glucan from Grifola frondosa for immune support.

Compound#56· moderate

Spirulina (Extra Profile)

Cyanobacterium with phycocyanin for allergy and immunity.

Mineral#57· moderate

Potassium Bicarbonate

Alkaline potassium salt that reduces bone resorption.

Mineral#58· moderate

Zinc Bisglycinate (High-Bio)

Chelated zinc with superior absorption and tolerability.

Mineral#59· moderate

Manganese (Extra)

Mn cofactor for SOD2 mitochondrial antioxidant defense.

Mineral#60· moderate

Boron (Extra)

Trace mineral that modulates steroid hormones and bone.

Mineral#61· moderate

Choline-Stabilized Orthosilicic Acid (ch-OSA)

Highly bioavailable silica for hair, skin, and bone.

Herb#62· moderate

Butterbur

Petasites hybridus extract for migraine prophylaxis and allergic rhinitis.

Herb#63· moderate

Cat's Claw

Uncaria tomentosa for joint pain and immunity.

Mushroom#64· moderate

Agaricus Blazei

Brazilian sun mushroom for immune support.

Mushroom#65· moderate

Phellinus Linteus

Meshima mushroom with hispolon for immune support.

Compound#66· moderate

PEA (Palmitoylethanolamide)

Endogenous fatty acid amide for pain and inflammation.

Amino Acid#67· moderate

L-Lysine

Essential amino acid for collagen and HSV prevention.

Compound#68· moderate

Vitamin D3 + K2

Synergistic combo for calcium routing.

Mineral#69· moderate

Bamboo Silica

Plant-based silicon for skin and bones.

Mineral#70· moderate

Choline-Stabilized OSA

Bioavailable silicon form.

Mineral#71· moderate

Selenium (Selenomethionine)

Antioxidant trace element for thyroid.

Compound#72· moderate

Quercetin Phytosome

Lecithin-complexed quercetin.

Compound#73· moderate

Quercetin + Bromelain

Anti-inflammatory pair for allergies.

Herb#74· moderate

Stinging Nettle Leaf

Urtica dioica leaf for allergies and joint pain.

Compound#75· moderate

Isoquercetin

Highly bioavailable quercetin glycoside.

Compound#76· moderate

Luteolin

Flavone with anti-inflammatory effects.

Compound#77· moderate

Baicalin

Scutellaria baicalensis flavonoid.

Herb#78· moderate

Pelargonium Sidoides

South African geranium for bronchitis.

Herb#79· moderate

EPs 7630

Standardized Pelargonium extract.

Herb#80· moderate

Echinacea Purpurea

Coneflower for upper respiratory infections.

Herb#81· moderate

Echinacea Angustifolia

Narrow-leaf coneflower for immune support.

Compound#82· moderate

Genistein

Soy isoflavone with bone benefits.

Mushroom#83· moderate

Lion's Mane Fruiting Body

Hericinones-rich beta-glucan source.

Mushroom#84· moderate

Agarikon (Fomitopsis officinalis)

Antiviral polypore mushroom.

Mushroom#85· moderate

Poria Cocos

TCM mushroom for sleep and immunity.

Mushroom#86· moderate

Oyster Mushroom

Pleurotus ostreatus with ergothioneine.

Herb#87· moderate

Butterbur Ze 339

PA-free butterbur for allergic rhinitis.

Herb#88· moderate

Marshmallow Root

Althaea officinalis mucilage for cough.

Herb#89· moderate

Cranberry Extract

Vaccinium macrocarpon for UTI prevention.

Herb#90· moderate

Olive Leaf (Standardized Oleuropein)

High-oleuropein extract.

Fatty Acid#91· moderate

Lauric Acid

Coconut MCFA with antimicrobial activity.

Fatty Acid#92· moderate

Black Seed Oil (Nigella sativa)

Thymoquinone for immune and metabolic health.

Compound#93· moderate

Thymoquinone

Active black seed compound.

Compound#94· moderate

Propolis

Bee glue with caffeic acid phenethyl ester.

Compound#95· moderate

Bee Pollen

Pollen collected by bees.

Compound#96· moderate

Manuka Honey

Leptospermum honey with MGO.

Compound#97· moderate

Bromelain

Pineapple proteolytic enzyme.

Mineral#98· moderate

Boron Citrate

Boron for hormone modulation.

Herb#99· moderate

Ginger Extract (Zingiber)

Standardized ginger for nausea and inflammation.

Herb#100· moderate

Galangal (Alpinia)

Thai ginger relative for inflammation.

Herb#101· moderate

Holy Basil (Tulsi)

Ocimum sanctum adaptogen.

Compound#102· moderate

Holy Basil Eugenol

Active constituent of tulsi.

Vitamin#103· moderate

Liposomal Vitamin C

Phospholipid-encapsulated vitamin C.

Vitamin#104· moderate

Ascorbyl Palmitate

Fat-soluble vitamin C ester.

Vitamin#105· moderate

Sodium Ascorbate

Buffered vitamin C form.

Compound#106· moderate

Bovine Colostrum

First milk with growth factors.

Compound#107· moderate

Chlorella

Green algae with chlorophyll.

Herb#108· moderate

Amla (Indian Gooseberry)

Phyllanthus emblica vitamin C source.

Fatty Acid#109· moderate

Black Cumin Seed Oil

Nigella sativa oil.

Fatty Acid#110· moderate

Cod Liver Oil

Traditional A, D, omega-3 source.

Mineral#111· limited

Boron

Trace mineral implicated in steroid hormone metabolism and bone integrity.

Herb#112· limited

Eleuthero

Adaptogen used to support stamina, immune function, and stress resilience.

Mineral#113· limited

Boron

Trace mineral with modest effects on free testosterone and bone mineralization.

Compound#114· limited

Quercetin

Flavonoid with antihistamine, anti-viral, and senolytic activity.

Mineral#115· limited

Silica (Silicon)

Trace element involved in collagen and connective tissue crosslinking.

Herb#116· limited

Horny Goat Weed

PDE5-inhibiting flavonoid (icariin) used for libido and erectile support.

Mushroom#117· limited

Chaga

Birch-tree mushroom rich in melanin, betulin, and antioxidants.

Compound#118· limited

Monolaurin

Coconut-derived monoglyceride with antimicrobial properties against enveloped viruses.

Herb#119· limited

Horsetail Extract

Silica-rich herb traditionally used for hair, nail, and connective tissue support.

Vitamin#120· limited

Vitamin C (Harm-Reduction Antioxidant)

Water-soluble antioxidant — quenches dopamine quinone and other reactive metabolites.

Mineral#121· limited

Zinc Picolinate

Zinc chelated to picolinic acid — one of the most bioavailable oral forms.

Mineral#122· limited

Zinc Bisglycinate

Glycine-chelated zinc — high absorption and very gentle on the stomach.

Compound#123· limited

Liposomal Glutathione

Phospholipid-encapsulated GSH — protects from gut breakdown for systemic delivery.

Herb#124· limited

Chinese Skullcap

Flavonoid-rich root used for anxiety and inflammation.

Peptide#125· limited

Thymulin (Reference)

Zinc-dependent thymic peptide that matures T-cells.

Mineral#126· limited

Calcium AEP (Membrane Calcium)

Cell-membrane-targeted form of calcium claimed for autoimmune support.