Overview
Mn cofactor for SOD2 mitochondrial antioxidant defense.
- Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
- Fortified foods such as cereals, breads, plant milks, and table salt
- Mineral supplements as chelates, citrates, glycinates, or inorganic salts
- Chelated form (glycinate, bisglycinate, citrate, malate)
- Inorganic salt (oxide, sulfate, chloride)
- Liquid ionic solution
- Topical or transdermal preparation
Forms & variants of Manganese
Different chemical forms of Manganese behave differently. Browse each form's mechanism, bioavailability, and best-use context.
Mechanism of action
Required by MnSOD; cofactor for glycosyltransferases in bone matrix.
- · Required by MnSOD
- · cofactor for glycosyltransferases in bone matrix
Effects on the body
Organ system effects
Manganese (Extra) contributes to bone mineralization, osteoblast activity, or calcium-phosphate homeostasis.
Evidence-based benefits
Combined with Ca/Zn/Cu reduces bone loss
Moderate evidencePotential side effects
- · Neurotoxicity at extreme doses
Drug interactions
Supplement interactions
- A high-quality multivitaminCovers micronutrient cofactors that support most supplement pathways.
- Omega-3 (EPA/DHA)Foundational anti-inflammatory support that complements most regimens.
No specific avoidances listed.
Dosing & bioavailability
Where to buy
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Third-party testedIndependently verified Manganese (Extra) — look for USP, NSF, or Informed Sport seals on the label for purity and dose accuracy.Manganese (Extra) third party tested NSF
CapsulesPre-measured Manganese (Extra) capsules — easiest for travel and consistent daily dosing without scoops or scales.Manganese (Extra) capsules
PowderBulk unflavored Manganese (Extra) powder — best cost-per-gram and flexible dosing for stacking or mixing into drinks.Manganese (Extra) powder unflavored
Best sellersMost-purchased Manganese (Extra) products on Amazon — a quick way to see what's reviewed widely before you commit.Manganese (Extra) best sellerScientific evidence8Show studiesHide studies
Trace minerals on bone density
Strause L, et al.
2-year DB-RCT in 59 postmenopausal women.
Ca + trace minerals (incl Mn) preserved spinal BMD vs Ca alone.
PubMed: Manganese (Extra) — Combined with Ca/Zn/Cu reduces bone loss
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PubMed: Manganese (Extra) — randomized controlled trial
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PubMed: Manganese (Extra) — dose response
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Google Scholar: Manganese (Extra) — clinical evidence
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