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evidence · mechanism · dose
Supplements/Mineral

Manganese (Extra)

Mn cofactor for SOD2 mitochondrial antioxidant defense.

Bone HealthGeneral Wellness

Overview

Mn cofactor for SOD2 mitochondrial antioxidant defense.

Natural sources
    Common forms

      Forms & variants of Manganese

      Different chemical forms of Manganese behave differently. Browse each form's mechanism, bioavailability, and best-use context.

      Parent
      Manganese

      Trace mineral cofactor for SOD, gluconeogenesis, and bone formation.

      Mechanism of action

      Required by MnSOD; cofactor for glycosyltransferases in bone matrix.

      Pathways

        Effects on the body

        Organ system effects

        Evidence-based benefits

        Combined with Ca/Zn/Cu reduces bone loss

        Moderate evidence

        Potential side effects

        Common
          Rare
          • · Neurotoxicity at extreme doses
          Serious

            Drug interactions

            No notable interactions reported.

            Supplement interactions

            Pairs well with

            None listed.

            Avoid combining with

            No specific avoidances listed.

            Dosing & bioavailability

            Typical dose
            2–5 mg
            With food?
            With food

            Where to buy

            Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

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            Thorne
            Practitioner-grade · NSF tested

            Scientific evidence (8)

            RCTJ Nutr · 1994

            Trace minerals on bone density

            Strause L, et al.

            2-year DB-RCT in 59 postmenopausal women.

            Key findings

            Ca + trace minerals (incl Mn) preserved spinal BMD vs Ca alone.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — Combined with Ca/Zn/Cu reduces bone loss

            Live PubMed search

            Live results for "Manganese (Extra) Combined with Ca/Zn/Cu reduces bone loss" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "Combined with Ca/Zn/Cu reduces bone loss". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — randomized controlled trial

            Live PubMed search

            Live results for "Manganese (Extra) randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — meta-analysis

            Live PubMed search

            Live results for "Manganese (Extra) meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — pharmacokinetics

            Live PubMed search

            Live results for "Manganese (Extra) pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — safety adverse events

            Live PubMed search

            Live results for "Manganese (Extra) safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewPubMed (NLM) · 1970

            PubMed: Manganese (Extra) — dose response

            Live PubMed search

            Live results for "Manganese (Extra) dose response" across the PubMed/MEDLINE peer-reviewed index.

            Key findings

            Opens current human and preclinical literature matching Manganese (Extra) and "dose response". Filter by RCT, meta-analysis, or year on the results page.

            Open study
            Systematic reviewGoogle Scholar · 1970

            Google Scholar: Manganese (Extra) — clinical evidence

            Live Scholar search

            Cross-database citation index for Manganese (Extra) as it relates to "clinical evidence".

            Key findings

            Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

            Open study
            Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.