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evidence · mechanism · dose
Supplements/Mineral

Strontium

aka Strontium citrate · Strontium ranelate (Rx)

Trace element that displaces Ca in bone and was approved (ranelate) for osteoporosis.

Bone Health

Overview

Trace element that displaces Ca in bone and was approved (ranelate) for osteoporosis.

Natural sources
  • Trace in seafood and grains
Common forms
  • Citrate (OTC)
  • Ranelate (Rx, withdrawn in some regions)

Forms & variants of Strontium

Different chemical forms of Strontium behave differently. Browse each form's mechanism, bioavailability, and best-use context.

Ranelate (Rx)
Strontium Ranelate (Ref)

Reference strontium salt used as anti-osteoporotic drug.

Mechanism of action

Increases osteoblast activity and reduces osteoclast activity; substitutes for calcium in hydroxyapatite.

Pathways
  • · Bone remodeling balance

Effects on the body

Increases
Bone mineral density (apparent on DEXA)

Organ system effects

Bones

Reduces fracture risk in postmenopausal osteoporosis.

Evidence-based benefits

Reduces vertebral fracture risk (ranelate)

Strong evidence

Potential side effects

Common
  • · GI upset
Rare
    Serious
    • · Cardiovascular events (ranelate, leading to restrictions)

    Drug interactions

    Calcium
    Compete for absorption — separate.
    minor

    Supplement interactions

    Pairs well with

    None listed.

    Avoid combining with
    • CV disease
      Ranelate safety signal.

    Dosing & bioavailability

    Typical dose
    680 mg strontium citrate/d (away from Ca)

    Where to buy

    Affiliate-style search links to reputable retailers. We don't endorse specific brands — verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Mineral
    Strontium
    Amazon
    Wide selection · fast shipping
    Mineral
    Strontium
    iHerb
    Global delivery · curated brands
    Mineral
    Strontium
    Thorne
    Practitioner-grade · NSF tested

    Scientific evidence (8)

    RCTN Engl J Med · 2004

    Strontium ranelate for postmenopausal osteoporosis (SOTI)

    Meunier PJ, et al.

    3-year RCT of strontium ranelate.

    Key findings

    Reduced vertebral fracture risk by 41%.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — Reduces vertebral fracture risk

    Live PubMed search

    Live results for "Strontium Reduces vertebral fracture risk" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "Reduces vertebral fracture risk". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — randomized controlled trial

    Live PubMed search

    Live results for "Strontium randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — meta-analysis

    Live PubMed search

    Live results for "Strontium meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — pharmacokinetics

    Live PubMed search

    Live results for "Strontium pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — safety adverse events

    Live PubMed search

    Live results for "Strontium safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium — dose response

    Live PubMed search

    Live results for "Strontium dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Strontium — clinical evidence

    Live Scholar search

    Cross-database citation index for Strontium as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.