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Supplements/Mineral

Strontium Citrate

Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

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Overview

Mineral that substitutes for calcium in bone — controversial but increases BMD measurements.

Natural sources
  • Whole foods (leafy greens, legumes, nuts, seeds, seafood, animal proteins)
  • Fortified foods such as cereals, breads, plant milks, and table salt
  • Mineral supplements as chelates, citrates, glycinates, or inorganic salts
Common forms
  • Chelated form (glycinate, bisglycinate, citrate, malate)
  • Inorganic salt (oxide, sulfate, chloride)
  • Liquid ionic solution
  • Topical or transdermal preparation

Mechanism of action

Replaces Ca²⁺ in hydroxyapatite, stimulating osteoblasts and inhibiting osteoclasts.

Pathways
  • · Replaces Ca²⁺ in hydroxyapatite, stimulating osteoblasts
  • · inhibiting osteoclasts

Effects on the body

Increases
BMD (strontium ranelate Rx — CV risk)

Organ system effects

Bones

Strontium Citrate contributes to bone mineralization, osteoblast activity, or calcium-phosphate homeostasis.

Evidence-based benefits

Increases BMD (strontium ranelate Rx — CV risk)

Moderate evidence

Potential side effects

Common
    Rare
    • · GI upset
    Serious
    • · CV/VTE risk (ranelate Rx)

    Drug interactions

    Calcium supplements
    Compete for absorption — separate by 2h.
    moderate

    Supplement interactions

    Pairs well with
    • A high-quality multivitamin
      Covers micronutrient cofactors that support most supplement pathways.
    • Omega-3 (EPA/DHA)
      Foundational anti-inflammatory support that complements most regimens.
    Avoid combining with

    No specific avoidances listed.

    Dosing & bioavailability

    Typical dose
    340–680 mg elemental Sr (citrate form)
    Best form
    Most evidence is based on the chelated form (glycinate, bisglycinate, citrate, malate) form.
    Timing
    Consistent daily timing recommended; split larger doses if GI tolerance is a concern.
    With food?
    Empty stomach away from calcium

    Where to buy

    Affiliate links — we may earn a commission at no extra cost to you. Amazon code supplementsch-20 is auto-applied at checkout. We don't endorse specific brands; verify third-party testing (USP, NSF, Informed Sport) before purchase.

    Scientific evidence8Show studies
    Systematic reviewOsteoporos Int · 2014

    Strontium citrate for bone density

    Reginster JY, et al.

    Review of strontium salts in osteoporosis.

    Key findings

    Improved BMD; cardiovascular caution with strontium ranelate.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — Increases BMD

    Live PubMed search

    Live results for "Strontium Citrate Increases BMD" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "Increases BMD". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — randomized controlled trial

    Live PubMed search

    Live results for "Strontium Citrate randomized controlled trial" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "randomized controlled trial". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — meta-analysis

    Live PubMed search

    Live results for "Strontium Citrate meta-analysis" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "meta-analysis". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — pharmacokinetics

    Live PubMed search

    Live results for "Strontium Citrate pharmacokinetics" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "pharmacokinetics". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — safety adverse events

    Live PubMed search

    Live results for "Strontium Citrate safety adverse events" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "safety adverse events". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewPubMed (NLM) · 1970

    PubMed: Strontium Citrate — dose response

    Live PubMed search

    Live results for "Strontium Citrate dose response" across the PubMed/MEDLINE peer-reviewed index.

    Key findings

    Opens current human and preclinical literature matching Strontium Citrate and "dose response". Filter by RCT, meta-analysis, or year on the results page.

    Open study
    Systematic reviewGoogle Scholar · 1970

    Google Scholar: Strontium Citrate — clinical evidence

    Live Scholar search

    Cross-database citation index for Strontium Citrate as it relates to "clinical evidence".

    Key findings

    Includes preprints, theses, and journal articles. Useful for tracking citation counts and follow-on work.

    Open study
    Educational use only. This profile is not medical advice. Consult a qualified healthcare professional before starting any supplement, especially if you take prescription medication or have a chronic condition.

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